Table 1 Pharmacokinetic parameters of the intravenous solution and intravenous nanosuspension doses
Parameter | Solution dose (n = 3) | Nanosuspension dose (n = 4) |
|---|---|---|
Route | Intravenous | Intravenous |
Target dose (mg/kg) | 3.0 | 2.5 |
C 0(μg/mL) | 2.5 ± 0.1 | 2.0 ± 0.2 |
t 1/2α(h) | 0.4 ± 0.1 | 0.4 ± 0.1 |
t 1/2β(h) | 3.9 ± 0.6 | 4.8 ± 0.9 |
V ss(mL/kg) | 2100 ± 130 | 3000 ± 530 |
CL (mL/min/kg) | 33.6 ± 0.9 | 35 ± 1.0 |
MRT (h) | 1.1 ± 0.1 | 1.5 ± 0.4 |
AUC0–∞(μg h/mL) | 1.5 ± 0.1 | 1.2 ± 0.1 |
Mean AUC0–∞(μg h/mL)/dose | 0.5 | 0.5 |