Figure 3

Histopathology of the liver tissue (×100 or ×200) in female mice after intraperitoneal injection with various doses of nano-anatase TiO₂suspensions for consecutive 14 days.a Control (×100): hepatocyte array is complete;b 5 mg/kg BW nano-anatase TiO₂(×100): hepatocyte is normal, sinus hepaticus is complete, vascellum is normal;c 100 mg/kg BW nano-anatase TiO₂(×100):Arrows indicate congestion of vascellum and prominent vasodilatation;d 150 mg/kg BW nano-anatase TiO₂(×200):Arrows indicate wide-bound basophilia;e 150 mg/kg BW nano-anatase TiO₂(×200):Arrows indicate focal ischemia;f 150 mg/kg BW bulk TiO₂(×100):Arrows indicate congestion of central veins