Figure 4

Ultrastructure of hepatocyte (×8,000 or ×10,000) in female mice after intraperitoneal injection with various doses of nano-anatase TiO₂suspensions for consecutive 14 days.a Control (×8,000): chromatin is well distributed, mitochondria turn round or oval and complete;b 5 mg/kg BW nano-anatase TiO₂(×8,000): hepatocyte indicates normal;c 100 mg/kg BW nano-anatase TiO₂(×10,000);arrows indicate tumescent mitochondria and vacuolization;d 150 mg/kg BW nano-anatase TiO₂(×10,000): apoptotic cell or apoptotic body is observed