Table 2 The changes of biochemical parameters in the blood serum of mouse liver after intraperitoneal injection with nano-anatase TiO2suspensions for consecutive 14 days
From: The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2
Indexes | Nano-anatase (mg/kg BW) | Bulk (mg/kg BW) | |||||
---|---|---|---|---|---|---|---|
0 | 5 | 10 | 50 | 100 | 150 | 150 | |
ALT (U/L) | 68.95 ± 3.45 | 72.66 ± 3.63 | 86.89 ± 0.34* | 99.18 ± 4.96* | 106.79 ± 5.34** | 129.33 ± 6.47** | 89.86 ± 4.49* |
ALP (U/L) | 208.59 ± 10.43 | 212.39 ± 10.62 | 234.72 ± 11.74 | 256.88 ± 12.84* | 282.36 ± 14.12** | 329.87 ± 16.49** | 228.96 ± 11.45** |
AST (U/L) | 199.73 ± 9.99 | 210.47 ± 10.52 | 236.68 ± 11.83 | 268.92 ± 13.45** | 297.55 ± 14.88** | 345.88 ± 17.29** | 246.78 ± 12.34** |
LDH (U/L) | 1,520 ± 76 | 1,623 ± 84 | 1,897 ± 95 | 2,318 ± 116* | 2,689 ± 134** | 2,949 ± 147** | 2,309 ± 115* |
PChE (U/L) | 1,169 ± 58 | 1,297 ± 65 | 1,409 ± 70 | 1,696 ± 85* | 1,988 ± 99** | 2,597 ± 130** | 1,647 ± 82* |
LAP (U/L) | 43.76 ± 2.19 | 47.25 ± 2.36 | 50.28 ± 2.51 | 56.81 ± 2.84* | 60.19 ± 3.01* | 63.66 ± 3.18* | 52.72 ± 2.64* |
TP (g/L) | 60.15 ± 3.01 | 61.06 ± 3.05 | 62.59 ± 3.13 | 65.34 ± 3.27* | 69.23 ± 3.46* | 72.85 ± 3.64* | 62.06 ± 3.10 |
ALB (g/L) | 34.22 ± 1.71 | 34.30 ± 1.72 | 34.79 ± 1.74 | 35.92 ± 1.80 | 37.23 ± 1.86* | 38.92 ± 1.95* | 34.34 ± 1.72 |
GLB (g/L) | 24.55 ± 1.23 | 24.98 ± 1.25 | 26.15 ± 1.31 | 27.44 ± 1.37* | 30.15 ± 1.51* | 33.57 ± 1.68** | 25.05 ± 1.25 |
ALB/GLB | 1.39 | 1.37 | 1.33 | 1.31* | 1.24* | 1.16** | 1.37 |
TBIL (μmol/L) | 1.35 ± 0.07 | 1.33 ± 0.07 | 1.29 ± 0.06 | 1.22 ± 0.06* | 1.19 ± 0.06* | 1.15 ± 0.06* | 1.30 ± 0.06 |
TG (mmol/L) | 1.66 ± 0.08 | 1.68 ± 0.08 | 1.72 ± 0.09 | 1.83 ± 0.09* | 2.07 ± 0.10* | 2.25 ± 0.11** | 1.79 ± 0.09 |
TCHO (mmol/L) | 3.19 ± 0.16 | 3.14 ± 0.16 | 3.21 ± 0.16 | 3.29 ± 0.16 | 3.51 ± 0.18* | 3.66 ± 0.18* | 3.57 ± 0.18* |
HDLC (mmol/L) | 2.86 ± 0.14 | 2.83 ± 0.14 | 2.91 ± 0.14 | 3.01 ± 0.15 | 3.34 ± 0.17* | 3.52 ± 0.18* | 3.36 ± 0.17* |
LDLC (mmol/L) | 0.26 ± 0.01 | 0.25 ± 0.01 | 0.22 ± 0.01 | 0.17 ± 0.01* | 0.15 ± 0.01* | 0.12 ± 0.01* | 0.19 ± 0.01 |