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Table 2 The changes of biochemical parameters in the blood serum of mouse liver after intraperitoneal injection with nano-anatase TiO2suspensions for consecutive 14 days

From: The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2

Indexes

Nano-anatase (mg/kg BW)

Bulk (mg/kg BW)

0

5

10

50

100

150

150

ALT (U/L)

68.95 ± 3.45

72.66 ± 3.63

86.89 ± 0.34*

99.18 ± 4.96*

106.79 ± 5.34**

129.33 ± 6.47**

89.86 ± 4.49*

ALP (U/L)

208.59 ± 10.43

212.39 ± 10.62

234.72 ± 11.74

256.88 ± 12.84*

282.36 ± 14.12**

329.87 ± 16.49**

228.96 ± 11.45**

AST (U/L)

199.73 ± 9.99

210.47 ± 10.52

236.68 ± 11.83

268.92 ± 13.45**

297.55 ± 14.88**

345.88 ± 17.29**

246.78 ± 12.34**

LDH (U/L)

1,520 ± 76

1,623 ± 84

1,897 ± 95

2,318 ± 116*

2,689 ± 134**

2,949 ± 147**

2,309 ± 115*

PChE (U/L)

1,169 ± 58

1,297 ± 65

1,409 ± 70

1,696 ± 85*

1,988 ± 99**

2,597 ± 130**

1,647 ± 82*

LAP (U/L)

43.76 ± 2.19

47.25 ± 2.36

50.28 ± 2.51

56.81 ± 2.84*

60.19 ± 3.01*

63.66 ± 3.18*

52.72 ± 2.64*

TP (g/L)

60.15 ± 3.01

61.06 ± 3.05

62.59 ± 3.13

65.34 ± 3.27*

69.23 ± 3.46*

72.85 ± 3.64*

62.06 ± 3.10

ALB (g/L)

34.22 ± 1.71

34.30 ± 1.72

34.79 ± 1.74

35.92 ± 1.80

37.23 ± 1.86*

38.92 ± 1.95*

34.34 ± 1.72

GLB (g/L)

24.55 ± 1.23

24.98 ± 1.25

26.15 ± 1.31

27.44 ± 1.37*

30.15 ± 1.51*

33.57 ± 1.68**

25.05 ± 1.25

ALB/GLB

1.39

1.37

1.33

1.31*

1.24*

1.16**

1.37

TBIL (μmol/L)

1.35 ± 0.07

1.33 ± 0.07

1.29 ± 0.06

1.22 ± 0.06*

1.19 ± 0.06*

1.15 ± 0.06*

1.30 ± 0.06

TG (mmol/L)

1.66 ± 0.08

1.68 ± 0.08

1.72 ± 0.09

1.83 ± 0.09*

2.07 ± 0.10*

2.25 ± 0.11**

1.79 ± 0.09

TCHO (mmol/L)

3.19 ± 0.16

3.14 ± 0.16

3.21 ± 0.16

3.29 ± 0.16

3.51 ± 0.18*

3.66 ± 0.18*

3.57 ± 0.18*

HDLC (mmol/L)

2.86 ± 0.14

2.83 ± 0.14

2.91 ± 0.14

3.01 ± 0.15

3.34 ± 0.17*

3.52 ± 0.18*

3.36 ± 0.17*

LDLC (mmol/L)

0.26 ± 0.01

0.25 ± 0.01

0.22 ± 0.01

0.17 ± 0.01*

0.15 ± 0.01*

0.12 ± 0.01*

0.19 ± 0.01

  1. Ranks marked with an asterisk or double asterisks means it is significantly different from the control (no nano-anatase or bulk TiO2) at the 5 or 1% confidence level, respectively. Values represent mean ± SE,n = 5

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