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Table 1 Propargylic substitution reactions of 1,3-diphenyl-2-propyn-1-ol with phenol using PMA@MSS@FeCo/GC a

From: Propargylic substitution reactions with various nucleophilic compounds using efficient and recyclable mesoporous silica spheres embedded with FeCo/graphitic shell nanocrystals

Entry Catalyst (PMA mol%) Time (min) Temp. (°C) Conv. (%)b TOF (−h)
1 0.03 mol% 30 50 79 5,267
PMA@FeCo/GC@MSS
2 0.05 mol% 5 50 81 19,440
PMA@FeCo/GC@MSS
3 0.05 mol% 10 50 94 11,280
PMA@FeCo/GC@MSS
4 0.05 mol% 20 50 97 5,820
PMA@FeCo/GC@MSS
5 0.05 mol% 30 50 100 4,000
PMA@FeCo/GC@MSS
6 0.1 mol% 30 25 93 1,860
PMA@FeCo/GC@MSS
7 0.1 mol% 30 50 100 2,000
PMA@FeCo/GC@MSS
8 0.05 mol% PMA 30 50 95 3,800
9 FeCo/GC@MSSc 30 50 0 -
10 SiO2c 30 50 0 -
11 Recovered from number 5 30 50 100 4,000
12 Recovered from number 11 30 50 100 4,000
13 Recovered from number 12 30 50 100 4,000
14 Recovered from number 13 30 50 100 4,000
  1. aReaction conditions: 1,3-diphenyl-2-propyn-1-ol (0.19 ml, 1.0 mmol), phenol (1.2 mmol), and acetonitrile (5.0 mL). bDetermined by 1H NMR spectroscopy. Yields are based on the amount of propargylic alcohol. CAmount of compound based on calculated content in 0.05 mol% PMA@FeCo/GC@MSS, respectively.