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Table 1 Experimental design matrix with observed values of the objectives variables of protein-loaded NPs

From: Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix

Experiment Code

X1

X2

X3

Z-Avea (nm)

Polydispersibility Indice

E.E.(%) ± SD (n= 6)

1

8.2

5

0.66

280.8

0.483

35.29 ± 0.07

2

8.2

5

0.24

309.5

0.286

38.82 ± 0.53

3

8.2

2

0.66

602.6

0.702

51.76 ± 0.28

4

8.2

2

0.24

1428.7

0.632

50.59 ± 0.46

5

5.5

6

0.45

291.2

0.378

48.82 ± 0.12

6

5.5

1

0.45

890.7

0.806

54.71 ± 0.09

7

5.5

3.5

0.8

355.4

0.567

42.94 ± 0.14

8

5.5

3.5

0.1

640.2

0.686

55.88 ± 0.10

9

2.8

5

0.66

337.0

0.492

44.12 ± 0.74

10

2.8

5

0.24

345.8

0.384

45.88 ± 0.67

11

2.8

2

0.66

651.0

0.712

50.00 ± 0.41

12

2.8

2

0.24

2503.5

0.762

52.35 ± 0.75

13

10

3.5

0.45

380.5

0.536

44.71 ± 0.69

14

1

3.5

0.45

1025.5

0.691

49.41 ± 0.21

15

5.5

3.5

0.45

429.2

0.555

47.06 ± 0.55

  1. X1 represents duration of homogenization (min); X2 represents agitation speed (krpm); X3 represents volume ratio of organic solvent phase to external aqueous phase (V/V); Z-Ave represents average particle size diameter; E.E. represents encapsulation efficiency.

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