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Table 1 Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to rats.

From: Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models

Parameters Unit DTX-loaded Polysorbate 80 micelles DTX-loaded Polysorbate 80/Phospholipid mixed micelles P
t 1/2α h 0.916 ± 0.608 0.919 ± 0.601 0.995
t 1/2β h 4.901 ± 2.453 6.726 ± 1.684 0.626
K 12 h-1 4.780 ± 2.525 2.886 ± 1.551 0.179
K 21 h-1 2.544 ± 1.187 2.376 ± 1.421 0.828
K 13 h-1 0.773 ± 0.581 2.350 ± 1.577 0.095
K 31 h-1 0.190 ± 0.122 0.376 ± 0.404 0.310
K 10 h-1 2.800 ± 0.897 2.735 ± 0.891 0.908
AUC0-12 h μg∙L-1∙h 2024.891 ± 287.679 2218.685 ± 407.753 0.379
Cl L∙h 0.038 ± 0.006 0.038 ± 0.007 0.468
  1. n = 6.
  2. Mean ± SD.