Table 1 Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to rats.
Parameters | Unit | DTX-loaded Polysorbate 80 micelles | DTX-loaded Polysorbate 80/Phospholipid mixed micelles | P |
---|---|---|---|---|
t 1/2α | h | 0.916 ± 0.608 | 0.919 ± 0.601 | 0.995 |
t 1/2β | h | 4.901 ± 2.453 | 6.726 ± 1.684 | 0.626 |
K 12 | h-1 | 4.780 ± 2.525 | 2.886 ± 1.551 | 0.179 |
K 21 | h-1 | 2.544 ± 1.187 | 2.376 ± 1.421 | 0.828 |
K 13 | h-1 | 0.773 ± 0.581 | 2.350 ± 1.577 | 0.095 |
K 31 | h-1 | 0.190 ± 0.122 | 0.376 ± 0.404 | 0.310 |
K 10 | h-1 | 2.800 ± 0.897 | 2.735 ± 0.891 | 0.908 |
AUC0-12 h | μg∙L-1∙h | 2024.891 ± 287.679 | 2218.685 ± 407.753 | 0.379 |
Cl | L∙h | 0.038 ± 0.006 | 0.038 ± 0.007 | 0.468 |