Table 2 Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to mice.

t _1/2α

h

0.682 ± 0.2088

0.634 ± 0.166

0.734

t _1/2β

h

15.790 ± 20.5700

5.695 ± 1.703

0.445

K ₁₂

h^-1

13.976 ± 7.9457

9.627 ± 6.878

0.440

K ₂₁

h^-1

2.198 ± 0.2320

2.739 ± 1.032

0.346

K ₁₃

h^-1

4.410 ± 1.4573

1.012 ± 0.687

0.022*

K ₃₁

h^-1

0.149 ± 0.108

0.155 ± 0.042

0.927

K ₁₀

h^-1

16.040 ± 12.268

14.245 ± 16.245

0.866

AUC_{0-8 h}

μg∙L^-1 ∙h

10466.290 ± 3122.821

11406.914 ± 5042.349

0.762

Cl

L∙h

0.009 ± 0.007

0.008 ± 0.003

0.776