Skip to main content

Table 2 Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to mice.

From: Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models

Parameters Unit DTX-loaded Polysorbate80 micelles DTX-loadedPolysorbate 80/Phospholipid mixed micelles P
t 1/2α h 0.682 ± 0.2088 0.634 ± 0.166 0.734
t 1/2β h 15.790 ± 20.5700 5.695 ± 1.703 0.445
K 12 h-1 13.976 ± 7.9457 9.627 ± 6.878 0.440
K 21 h-1 2.198 ± 0.2320 2.739 ± 1.032 0.346
K 13 h-1 4.410 ± 1.4573 1.012 ± 0.687 0.022*
K 31 h-1 0.149 ± 0.108 0.155 ± 0.042 0.927
K 10 h-1 16.040 ± 12.268 14.245 ± 16.245 0.866
AUC0-8 h μg∙L-1 ∙h 10466.290 ± 3122.821 11406.914 ± 5042.349 0.762
Cl L∙h 0.009 ± 0.007 0.008 ± 0.003 0.776
  1. n = 4. Mean ± SD.
  2. * P < 0.05, denotes significant difference between two groups.