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Table 4 The AUCa of DTX in mice (n = 4) tissues after i.v. administration of DTX Polysorbate 80 micelles injection and DTX Polysorbate 80/Phospholipid mixed micelles injection.

From: Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models

Tissues DTX-loaded Polysorbate 80 micelles(μg·h·g-1) DTX-loaded Polysorbate 80/Phospholipid mixed micelles(μg·h·g-1) Ratio b
Plasma 10.466 11.407 1.090
Heart 74.263 99.451 1.339
Liver 42.081 71.695 1.704
Spleen 94.203 110.134 1.169
Lung 102.941 103.642 1.007
Ovary and uterus 84.217 104.152 1.237
Kidney 117.103 144.046 1.230
  1. aAUC of the tissues, 0 to 8 h.
  2. bThe ratio was AUCPolysorbate 80/Phospholipid mixed micelles/AUCPolysorbate80 micelles.