Table 4 The AUCa of DTX in mice (n = 4) tissues after i.v. administration of DTX Polysorbate 80 micelles injection and DTX Polysorbate 80/Phospholipid mixed micelles injection.
Tissues | DTX-loaded Polysorbate 80 micelles(μg·h·g-1) | DTX-loaded Polysorbate 80/Phospholipid mixed micelles(μg·h·g-1) | Ratio b |
---|---|---|---|
Plasma | 10.466 | 11.407 | 1.090 |
Heart | 74.263 | 99.451 | 1.339 |
Liver | 42.081 | 71.695 | 1.704 |
Spleen | 94.203 | 110.134 | 1.169 |
Lung | 102.941 | 103.642 | 1.007 |
Ovary and uterus | 84.217 | 104.152 | 1.237 |
Kidney | 117.103 | 144.046 | 1.230 |