Table 1 Predicted dug absorption (at C max) versus in vivo data (Wagner-Nelson equation) based on the surface area model
Dose/Drug absorbed in mg (impact by surface area only) | In vivo(Wagner-Nelson equation) mg | Predicted (mg) | Total surface area of the drug dose (cm2) | Absorption efficiency (AE) mg/cm2 |
---|---|---|---|---|
3 mg/kg (regular suspension) | 0.02 | 0.02 | 2.08 E0 | 9.0E-6 |
10 mg/kg (nano suspension) | 0.84 | 1.01 | 1.38 E2 | 7.2 E-6 |
30 mg/kg (nano suspension) | 1.11 | 3.03 | 4.15 E2 | 2.6E-6 |