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Table 1 Predicted dug absorption (at C max) versus in vivo data (Wagner-Nelson equation) based on the surface area model

From: Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery

Dose/Drug absorbed in mg (impact by surface area only)

In vivo(Wagner-Nelson equation) mg

Predicted (mg)

Total surface area of the drug dose (cm2)

Absorption efficiency (AE) mg/cm2

3 mg/kg (regular suspension)

0.02

0.02

2.08 E0

9.0E-6

10 mg/kg (nano suspension)

0.84

1.01

1.38 E2

7.2 E-6

30 mg/kg (nano suspension)

1.11

3.03

4.15 E2

2.6E-6

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