Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery

Table 2 SC dose exposure comparison (nanosuspension versus regular suspension)

Dose (mg/kg)	C _max(μM) ± STDEV	C _min24hr(μM) ± STDEV	AUC_0-t(h*μM) ± STDEV	t_1/2(h) ± STDEV
30 mg/kg (nanosuspension)	0.82 ± 0.03	0.20 ± 0.02	11.0 ± 0.5	10.2 ± 0.8
30 mg/kg (regular suspension)	0.13 ± 0.02	0.06 ± 0.02	2.0 ± 0.8	34.4 ± 21.4