Table 2 Hydrodynamic diameter, polydispersity, zeta potential, and encapsulation efficiency of several drug-loaded liposomes
Drug-loaded liposomes | Hydrodynamic diameter (nm) (mean ± SD) | Polydispersity (mean ± SD) | Zeta potential (mV) (mean ± SD) | Encapsulation efficiency |
|---|---|---|---|---|
DPPC/Ch/DSPE-PEG (5:5:1) | 115.4 ± 0.5 | 0.15 ± 0.01 | -30 ± 1 | 97% |
1 week after | 116 ± 2 | 0.15 ± 0.01 | ||
2 weeks after | 116.0 ± 0.8 | 0.15 ± 0.01 | ||
DSPC/Ch/DSPE-PEG (5:5:1) | 120 ± 2 | 0.19 ± 0.01 | -27 ± 4 | 96% |
Egg-PC/Ch/DSPE-PEG (5:5:1) | 104.3 ± 0.6 | 0.25 ± 0.01 | -19 ± 2 | 99% |
Egg-PC/DCP/Ch (7:2:1) | 79.3 ± 0.8 | 0.37 ± 0.01 | -39 ± 3 | 98% |
Egg-PC/Ch/DPPG (6.25:3:0.75) | 103.5 ± 0.9 | 0.12 ± 0.01 | -52 ± 6 | 98% |
2 weeks after | 95.4 ± 0.5 | 0.14 ± 0.01 | ||
Egg-PC/DPPG/DSPE-PEG (5:5:1) | 104 ± 3 | 0.27 ± 0.01 | -43 ± 3 | 99% |