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Table 1 Pharmacokinetic parameters of DHA

From: An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs

Parameters	DHA N/O/W emulsion	DHA O/W emulsion	DHA solution
t_1/2α (min)	9.40 ± 0.28^,*	3.97 ± 0.34	3.10 ± 0.09
t_1/2β (min)	160.91 ± 47.21^,*	73.31 ± 1.61*	20.20 ± 6.56
Cl (ml·min⁻¹·kg)	0.0023 ± 0.0002^,*	0.0038 ± 0.0002*	0.0069 ± 0.0013
AUC (min·ng·ml⁻¹)	219,759.00 ± 14,782.77^,*	131,564.5 ± 8,396.89*	73,025.35 ± 14,149.00
MRT (min)	97.65 ± 20.27^,*	32.22 ± 4.03*	9.40 ± 2.44

Parameters of DHA after intravenous administration of DHA N/O/W emulsion to rabbits, DHA solution, and DHA O/W emulsion as controls. The results are expressed as mean ± S.D. (n = 6), *P < 0.01 vs. DHA solution, **P < 0.01 vs. DHA O/W emulsion.

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