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Table 2 In vivo anti-tumor effects of DHA and DHA N/O/W emulsion on growth of H 22 tumor in ICR mice (n = 10)

From: An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs

Group

Dose (mg/kg)

Body weight (g) (initial/endpoint)

Tumor weight (g)

TIR (%)

NS control

-

21.9 ± 1.3/27.8 ± 2.2

1.4 ± 0.4

-

DHA solution

11.25

21.2 ± 1.2/25.3 ± 1.7

1.1 ± 0.3

21.5*

DHA N/O/W (low dose)

11.25

22.3 ± 0.9/28.6 ± 2.3

1.1 ± 0.2

23.0*

DHA N/O/W (high dose)

45.00

21.7 ± 1.1/26.3 ± 3.8

0.7 ± 0.2

51.8**

  1. Note: *P < 0.05 and **P < 0.01 vs. N.S. control.
  2. #P < 0.05 vs. DHA solution or low-dose group.

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