Table 1 Calculated release parameters of different formulations containing melatonin-loaded nanocapsules, according to the bi-exponential model
Formulation | Parameter | |||
---|---|---|---|---|
A | B | k1(min−1) | k2(min−1) | |
NC | 0.88 ± 0.10 | 0.15 ± 0.11 | 0.0073 ± 0.0005 | 0.0017 ± 0.0011 |
D-NC-L | 0.80 ± 0.02 | 0.28 ± 0.00 | 0.0058 ± 0.0002 | 0.0003 ± 0.0000 |
D-NC-M | 0.78 ± 0.01 | 0.24 ± 0.02 | 0.0043 ± 0.0004 | 0.0004 ± 0.0001 |
G-NC | 0.27 ± 0.04 | 0.72 ±0.04 | 0.0120 ± 0.0011 | 0.0016 ± 0.0001 |
G-NC-L | 0.16 ±0.01 | 0.84 ± 0.00 | 0.1647 ± 0.0012 | 0.0012 ± 0.0000 |
G-NC-M | 0.21 ± 0.10 | 0.74 ± 0.01 | 0.0072 ± 0.0002 | 0.0008 ± 0.0000 |