Figure 1From: Preparation and optimization of matrix metalloproteinase-1-loaded poly(lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodologyResponse surface plots of mean particle size ( Y 1) and entrapment efficiency ( Y 2) versus three factors. X1 = duration of homogenization (min), X2 = agitation speed (krpm), and X3 = volume ratio of organic solvent phase to external aqueous phase (V/V). (A, B, C) The effect of duration of homogenization, agitation speed and volume ratio of organic solvent phase to external aqueous phase on the mean particle size. (D, E, F) The effect of duration of homogenization, agitation speed and volume ratio of organic solvent phase on the (EE)%.Back to article page