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Table 1 Independent variables and their corresponding variables of NP preparation for RCCD

From: Preparation and optimization of matrix metalloproteinase-1-loaded poly(lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodology

Variables Levels
−1.682 −1 0 +1 +1.682
X1 (min) 2 4 7 10 12
X2 (krpm) 2 2.8 4 5.2 6
X 3 0.1 0.18 0.3 0.42 0.5
  1. RCCD, rotatable central composite design; X1, duration time of homogenization; X2, agitation speed of homogenization; X3, volume ratio of organic solvent phase to external aqueous phase.