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Table 2 RCCD consisting of three experimental factors in coded and actual levels with experimental results

From: Preparation and optimization of matrix metalloproteinase-1-loaded poly(lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodology

Formulation

Coded independent variables

Actual independent variables

Dependent variables

X 1

X 2

X 3

X 1

X 2

X 3

EE (%)

Mean size

1

1

1

1

10

5.2

0.42

36.96

381.2

2

1

1

−1

10

5.2

0.18

28.12

321.1

3

1

−1

1

10

2.8

0.42

42.74

510.2

4

1

−1

−1

10

2.8

0.18

41.09

770.2

5

−1

1

1

4

5.2

0.42

49.08

426.3

6

−1

1

−1

4

5.2

0.18

44.67

371.9

7

−1

−1

1

4

2.8

0.42

61.98

806.7

8

−1

−1

−1

4

2.8

0.18

54.10

1,216.6

9

+1.682

0

0

12

4

0.3

20.14

420.6

10

−1.682

0

0

2

4

0.3

60.50

790.1

11

0

+1.682

0

7

4

0.3

32.38

362.7

12

0

−1.682

0

7

2

0.3

50.14

980.1

13

0

0

+1.682

7

4

0.5

47.22

522.2

14

0

0

−1.682

7

4

0.1

32.19

539.8

15 to 20

0

0

0

7

4

0.3

37.38

471.1

  1. n = 3. EE, entrapment efficiency; RCCD, rotatable central composite design; X1, duration time of homogenization; X2, agitation speed of homogenization; X3, volume ratio of organic solvent phase to external aqueous phase.

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