Table 1 Physical properties of liposomes
From: Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging
Liposome formulation | Mean particle diameter | Zeta potential | DOX-Encapsulation efficiency | Amount of Gd(III) |
|---|---|---|---|---|
(molar ratio of lipids) | ||||
(nm) | (mV) | (%) | (mM) | |
GdSL1 | 157.1 ± 8.9 | −27.6 ± 4.2 | 46.6 ± 12.7 | 4.60 ± 0.16 |
Gd(III)-DOTA-DSPE/CHOL/DSPE-mPEG2000 = 31:15:4) | ||||
GdSL2 | 156.4 ± 5.1 | −21.9 ± 1.0 | 41.7 ± 9.7 | 3.17 ± 0.01 |
Gd(III)-DOTA-DSPE/CHOL/DSPE-mPEG2000/DSPE = 20:15:4:11) | ||||
GdSL3 | 131.4 ± 9.1 | −31.6 ± 7.2 | 62.9 ± 1.5 | 2.01 ± 0.31 |
Gd(III)-DOTA-DSPE/CHOL/DSPE-mPEG2000/DSPE = 10:15:4:21) | ||||
SL | 129.1 ± 6.6 | −31.9 ± 2.3 | 97.5 ± 0.4 | ND |
(CHOL/DSPE-mPEG2000/DSPE = 15:4:31) |