Table 3 QD delivery systems
From: Quantum dots: synthesis, bioapplications, and toxicity
Authors | Delivery system of QD | Use |
|---|---|---|
Jia et al. [142] | Multiwalled carbon nanotube (MWNT) delivery system | MWNTs are containing antisense oligodeoxynucleotides and CdTe QDs via electrostatically layer-by-layer assembling. |
Chen et al. [143], Xue et al. [144], Delehanty et al. [145], Ruan et al. [146], Wei et al.[147] | Tat peptide-mediated delivery system | QDs conjugated to the cell-penetrating peptide derived from the human immunodeficiency virus-1 transactivator protein |
Lagerholm et al. [148] | Peptide delivery system | Nine residue biotinylated l-arginine peptide is used to enhance delivery of streptavidin-conjugated QDs into mammalian cells. |
Bagalkot et al. [149] | A10 RNA aptamer | Functionalizes the surface of QD with the A10 RNA aptamer, which recognizes the extracellular domain of the prostate specific membrane antigen |
Bakalova et al. [150] | Silica-shelled quantum dots | Based on silica-shelled single QD micelles with incorporated paramagnetic substances [tris(2,2,6,6-tetramethyl-3,5-heptanedionate)/gadolinium] into the micelle and/or silica coat |
Yum et al. [151] | Nanoscale mechanochemical method | Using a membrane-penetrating nanoneedle |
Yuan et al. [152] | Chitosan (N-acetylglucosamine) tumor-targeted drug delivery | QDs encapsulated with chitosan |
Hasegawa et al. [48] | Nanogel-QD hybrid | Nanogels of CHPNH 2 with 15 amino groups per 100 glucose units and QDs that were conjugated with protein A molecules were mixed. |
Dixit et al. [141] | Viral vectors | QDs encapsulation in viral capsids |
Zhang and Liu [153] | Nonviral vectors | Cappingthe surface of ZnO QD with poly(2-(dimethylamino) ethyl methacrylate) |
Jablonski et al. [154] | Cationic peptide and a hydrophobic counterion | Quantum dots have been delivered to the cytosol of living cells using a combination of a cationic peptide, polyarginine, and a hydrophobic counterion, pyrenebutyrate. |
Qi and Gau [155] | QD-amphipol nanocomplex | Advantages include cytoplasm delivery and endosome escape. |
Gao et al. [109] | Polymeric delivery system | The structural design involves encapsulating QDs with an ABC triblock copolymer and linking this amphiphilic polymer. |
Duan and Nie [77] | Polymeric delivery system | QDs were encapsulated by PEI-g-PEG. |