Figure 1

SWNHs inhibited mitotic entry of N9 cells, especially in pre-treated with LPS. To assure how the SWNHs affect cellular mitosis, we incorporated BrdU into the control. We found that the accumulation of mitotic N9 cells pre-treated with or without LPS was significantly delayed by SWNHs at every time point followed with the increasing concentrations of SWNHs (P < 0.01), and the accumulation of mitotic N9 cells pre-treated with LPS (B) were much more than that without LPS (A). The mitotic entry of N9 cells pre-treated with LPS (D) was more than N9 cells (C). SWNHs inhibited mitotic entry of N9 cells pre-treated with or without LPS significantly at every time point followed with the increasing concentrations of SWNHs (P < 0.01). The mitotic entry inhibited by SWNHs in N9 cells pre-treated with LPS (D) was more significant than N9 cells (C). All data are represented as mean ± SEM.