Table 5 Diversification of rat major organ weight
From: Systematic safety evaluation on photoluminescent carbon dots
Gender | Dose | Body weight (g) | Liver | Spleen | Kidney | Ovarian/testis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Wet weight (g) | Liver/body (%) | Wet weight (g) | Spleen/body (%) | Wet weight (g) | Kidney/body (%) | Wet weight (g) | Organs/body (%) | |||
Female | Negative control | 235.9 ± 17.2 | 6.74 ± 0.66 | 2.86 ± 0.22 | 0.60 ± 0.07 | 0.26 ± 0.03 | 1.78 ± 0.14 | 0.75 ± 0.05 | 0.24 ± 0.07 | 0.10 ± 0.03 |
Low | 235.8 ± 12.8 | 6.92 ± 0.53 | 2.94 ± 0.20 | 0.59 ± 0.04 | 0.25 ± 0.02 | 1.70 ± 0.12 | 0.72 ± 0.03 | 0.27 ± 0.05 | 0.12 ± 0.02 | |
Middle | 234.9 ± 13.9 | 6.61 ± 0.53 | 2.83 ± 0.30 | 0.59 ± 0.03 | 0.25 ± 0.01 | 1.71 ± 0.09 | 0.73 ± 0.05 | 0.25 ± 0.05 | 0.11 ± 0.02 | |
High | 230.8 ± 20.6 | 6.67 ± 0.90 | 2.88 ± 0.22 | 0.56 ± 0.07 | 0.24 ± 0.02 | 1.76 ± 0.12 | 0.76 ± 0.03 | 0.26 ± 0.06 | 0.11 ± 0.02 | |
Male | Negative control | 362.5 ± 22.7 | 12.52 ± 1.94 | 3.44 ± 0.34 | 0.91 ± 0.14 | 0.25 ± 0.04 | 2.79 ± 0.25 | 0.77 ± 0.05 | 3.13 ± 0.13 | 0.86 ± 0.03 |
Low | 352.9 ± 17.8 | 11.21 ± 1.05 | 3.18 ± 0.24 | 0.90 ± 0.08 | 0.25 ± 0.02 | 2.65 ± 0.23 | 0.75 ± 0.07 | 3.19 ± 0.16 | 0.90 ± 0.06 | |
Middle | 354.1 ± 27.0 | 11.22 ± 1.02 | 3.18 ± 0.30 | 0.86 ± 0.10 | 0.24 ± 0.03 | 2.61 ± 0.16 | 0.74 ± 0.05 | 3.21 ± 0.18 | 0.91 ± 0.04 | |
High | 362.1 ± 15.3 | 11.16 ± 0.91 | 3.08 ± 0.26 | 0.90 ± 0.72 | 0.25 ± 0.02 | 2.66 ± 0.16 | 0.73 ± 0.04 | 3.21 ± 0.19 | 0.89 ± 0.05 | |