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Table 1 Blood parameters of SD rats treated with the different formulations for 3 weeks
From: Gemcitabine-loaded albumin nanospheres (GEM-ANPs) inhibit PANC-1 cells in vitro and in vivo
| Parameters | Formulation (n= 6, p> 0.05) | |||||||
|---|---|---|---|---|---|---|---|---|
| 110-nm GEM-ANPs | 406-nm GEM-ANPs | Gemcitabine | ANPs | Control | ||||
| Normal dose | High dose | Normal dose | High dose | Normal dose | High dose | High dose | - | |
| WBC (109/L) | 7.3 ± 1.1 | 5.3 ± 2.0 | 6.1 ± 1.2 | 5.1 ± 2.2 | 6.1 ± 1.3 | 4.8 ± 2.8 | 8.2 ± 2.2 | 7.3 ± 1.9 |
| RBC (1012/L) | 5.6 ± 1.8 | 6.2 ± 1.6 | 6.2 ± 2.1 | 6.1 ± 1.1 | 6.5 ± 2.9 | 6.0 ± 2.0 | 6.6 ± 2.9 | 6.4 ± 1.2 |
| Hb (g/L) | 130.0 ± 23.0 | 134.0 ± 20.0 | 141.0 ± 14.0 | 138.0 ± 16.0 | 139.0 ± 20.0 | 132.0 ± 16.0 | 148.0 ± 23.0 | 143.0 ± 19.0 |
| ALT (U/L) | 44.8 ± 14.0 | 52.5 ± 12.9 | 46.0 ± 11.3 | 54.3 ± 12.8 | 51.8 ± 15.3 | 60.2 ± 21.9 | 44.7 ± 11.5 | 48.8 ± 13.2 |
| AST (U/L) | 109.1 ± 22.1 | 128.0 ± 31.8 | 115.5 ± 26.0 | 113.1 ± 26.9 | 129.4 ± 28.1 | 136.3 ± 33.4 | 113.3 ± 28.4 | 109.5 ± 25.7 |
| Cr (mM/L) | 7.1 ± 2.4 | 8.7 ± 3.2 | 6.2 ± 1.5 | 7.8 ± 2.07 | 6.1 ± 1.9 | 7.4 ± 2.2 | 4.9 ± 1.5 | 6.1 ± 1.6 |
| BUN (μM/L) | 41.0 ± 15.1 | 45.5 ± 17.3 | 35.4 ± 16.0 | 40.9 ± 19.5 | 36.1 ± 18.2 | 45.0 ± 13.7 | 47.2 ± 16.2 | 41.3 ± 18.6 |
