Gemcitabine-loaded albumin nanospheres (GEM-ANPs) inhibit PANC-1 cells in vitro and in vivo

Nanoscale Research Letters

Table 4 The inhibition rate of GEM-ANPs on tumor growth in the PANC-1-induced nude mice tumor model

Group	Tumor volume (mm³)		Volume change, ΔV(mm³)	Inhibitory rate of volume^a(%)	Tumor weight^b(g)	Inhibitory rate of weight^c(%)
	5 days	35 days
110-nm GEM-ANPs	144.9 ± 12.2	187.3 ± 32.4	42.4	75.1	0.175	39.9
406-nm GEM-ANPs	148.2 ± 10.4	31.0 ± 16.1	−117.2	168.8^*	0.090^*	69.1^*
Gemcitabine	149.64 ± 20.35	132.80 ± 28.2	−16.8	109.9	0.166	43.0
ANPs	147.6 ± 22.7	250.6 ± 27.2	103.0	39.6	0.245	15.81
Control	149.4 ± 18.2	319.9 ± 30.3	170.5	0.0	0.291	0.0

n = 30. ^aInhibition rate of tumor volume = (Differences in mean tumor volume between the beginning and end of treatment group) / (differences in mean tumor volume between the begin and end of control group) × 100%. ^bThe tumor weight was measured at 35 days after administration. ^cInhibition rate of tumor weight = (Differences in mean tumor weight between treatment group and control group) / (Mean tumor weight of control group) × 100%. ^*Significant difference compared with gemcitabine group, p < 0.05.