Table 1 Different supercritical fluid methods utilized for liposomes production
Method | Phospholipid composition | Active ingredient | Particle size | Reference |
---|---|---|---|---|
Supercritical liposome method | Phosphatidylcholine, phosphatidylserine, and cholesterol | FITC-dextran and TSZnPc | ~200 nm | [27] |
Rapid expansion of supercritical solution process | Phosphatidylcholine and cholesterol | Atractylodes macrocephala essential oil | ~173 nm | [28] |
Depressurization of an expanded solution into aqueous media | Diastearoylphosphatidylcholine and cholesterol | - | 50 to 200 nm | [29] |
Solution-enhanced dispersion by supercritical fluid process | Soy phospholipids | Puerarin | 1 μm | |
Gas anti-solvent process | Soy phospholipids | - | - | [31] |
Phosphatidylcholine and cholesterol | Amphotericin B | 0.5 to 3 μm | [32] | |
Aerosol solvent extraction system | Phosphatidylcholine and cholesterol | Miconazole | DNS | [33] |
Supercritical anti-solvent process | Lecithins S20, S75, and S100 | - | 1 to 40 μm | [34] |
Lecithin S75 | - | 1 to 40 μm | [35] | |
Lecithin S75 | Fluorescent markers | 0.1 to 100 μm | [26] | |
Hydrogenated soy phosphatidylcholine, soy phosphatidylcholine, and cholesterol | Docetaxel | 200 to 300 nm | [36] | |
Hydrogenated soy phosphatidylcholine | Vitamin D3 | 1 μm | [37] | |
Hydrogenated soy phosphatidylcholine | Lutein | 200 to 500 nm | [38] | |
Continuous anti-solvent process | Soy lecithin | - | 0.1 to 100 μm | |
Supercritical reverse-phase evaporation | Dipalmitoylphosphatidylcholine | Glucose and cholesterol | 0.1 to 1.2 μm | [41] |
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid | Glucose and cholesterol | 0.1 to 1.2 μm | [42] | |
Phosphatidylcholine and dioleoylphosphatidylcholine | Glucose | 0.1 to 1.2 μm | [14] | |
Improved supercritical reverse-phase evaporation | Dipalmitoylphosphatidylcholine | Glucose | 1.5 μm |