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Table 1 Physicochemical properties of uncoated and lipid-coated SPIONs in different buffer solutions at pH 7.4

From: Stability and magnetically induced heating behavior of lipid-coated Fe3O4 nanoparticles

Buffer system

Particle concentration (mg/mL)

Particle size (nm)

Zeta potential (mV)

Uncoated SPIONs

Lipid-coated SPIONs

Uncoated SPIONs

Lipid-coated SPIONs

 

1.0

520.0 ± 45.4

651.6 ± 25.3

-32.4 ± 1.0

-11.9 ± 1.4

Citrate, pH 7.4

0.24

286.6 ± 25.4

460.3 ± 15.4

-40.7 ± 1.4

-15.6 ± 1.4

 

0.02

80.0 ± 1.7*

179.3 ± 35.0**

-47.1 ± 2.6*

-19.1 ± 1.3**

 

1.0

1860.0 ± 180.9a

2422.0 ± 223.5a

-11.2 ± 1.0

-4.5 ± 0.9

HBSS, pH 7.4

0.24

1255.0 ± 35.2a

1560.0 ± 135.2a

-12.3 ± 1.1

-5.5 ± 1.0

 

0.02

580.0 ± 8.5

193.5 ± 32.6**

-23.3 ± 0.8

-7.4 ± 1.4

 

1.0

2800.0 ± 320.4a

2990.0 ± 412.5a

-10.3 ± 0.5

-2.2 ± 0.6

PBS, pH 7.4

0.24

2214.0 ± 45.3a

2500.0 ± 245.3a

-10.8 ± 1.0

-3.4 ± 1.1

 

0.02

931.0 ± 4.5

229.9 ± 12.42**

-22.5 ± 0.8

-5.2 ± 1.6

  1. Data are represented as mean ± SD (n = 4).
  2. aValue outside qualification range of Zetasizer Nano-ZS.
  3. *Significantly different from uncoated control SPIONs (p < 0.05).
  4. **Significantly different from lipid-coated SPIONs (p < 0.05).

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