A comparative study of lung toxicity in rats induced by three types of nanomaterials

Lin, Zhiqing; Ma, Li; X, Zhu-ge; Zhang, Huashan; Lin, Bencheng

doi:10.1186/1556-276X-8-521

Table 5 Relative volumes of significantly altered protein spots isolated from lung samples of rats

From: A comparative study of lung toxicity in rats induced by three types of nanomaterials

Spot	Control	H-nano-SiO₂	L-nano-SiO₂	H-nano-Fe₃O₄	L-nano-Fe₃O₄	H-SWCNTs	L-SWCNTs
1	0.103 ± 0.020	0.195 ± 0.019^a	0.184 ± 0.012^a	0.162 ± 0.016^a	0.172 ± 0.014^a	0.160 ± 0.026^a	0.194 ± 0.033^a
2	0.087 ± 0.020	0.024 ± 0.011^a	0.012 ± 0.003^a	0.027 ± 0.008^a	0.039 ± 0.014^a	0.020 ± 0.010^a	0.026 ± 0.005^a
3	0.330 ± 0.039	0.128 ± 0.021^a	0.182 ± 0.030^a	0.200 ± 0.038^a	0.143 ± 0.016^a	0.140 ± 0.015^a	0.182 ± 0.059^a
4	0.356 ± 0.049	0.203 ± 0.015^a	0.215 ± 0.022^a	0.226 ± 0.011^a	0.231 ± 0.026^a	0.201 ± 0.023^a	0.208 ± 0.019^a
5	0.014 ± 0.006	0.032 ± 0.008^a	0.030 ± 0.006^a	0.031 ± 0.005^a	0.032 ± 0.004^a	0.040 ± 0.005^a	0.031 ± 0.003^a
6	0.193 ± 0.030	0.405 ± 0.047^a	0.382 ± 0.045^a	0.404 ± 0.044^a	0.400 ± 0.050^a	0.434 ± 0.024^a	0.400 ± 0.037^a
7	0.036 ± 0.007	0.012 ± 0.001^a	0.017 ± 0.003^a	0.012 ± 0.002^a	0.017 ± 0.001^a	0.012 ± 0.002^a	0.013 ± 0.003^a
8	0.053 ± 0.020	0.151 ± 0.020^a	0.136 ± 0.044^a	0.146 ± 0.021^a	0.137 ± 0.007^a	0.140 ± 0.029^a	0.140 ± 0.013^a
9	0.038 ± 0.006	0.016 ± 0.004^a	0.017 ± 0.003^a	0.017 ± 0.003^a	0.019 ± 0.007^a	0.010 ± 0.008^a	0.013 ± 0.007^a
10	0.092 ± 0.028	0.257 ± 0.027^a	0.245 ± 0.020^a	0.228 ± 0.039^a	0.219 ± 0.031^a	0.264 ± 0.040^a	0.214 ± 0.029^a
11	0.098 ± 0.013	0.016 ± 0.004^a	0.024 ± 0.006^a	0.018 ± 0.003^a	0.023 ± 0.003^a	0.013 ± 0.004^a	0.022 ± 0.004^a
12	0.030 ± 0.003	0.189 ± 0.051^a	0.158 ± 0.036^a	0.186 ± 0.044^a	0.132 ± 0.022^a	0.196 ± 0.027^a	0.160 ± 0.044^a
13	0.153 ± 0.020	0.031 ± 0.018^a	0.059 ± 0.020^a	0.045 ± 0.021^a	0.070 ± 0.029^a	0.040 ± 0.029^a	0.054 ± 0.029^a
14	0.012 ± 0.003	0.038 ± 0.008^a	0.031 ± 0.007^a	0.049 ± 0.009^a	0.032 ± 0.005^a	0.043 ± 0.009^a	0.037 ± 0.007^a
15	0.051 ± 0.008	0.135 ± 0.027^a	0.109 ± 0.018^a	0.126 ± 0.013^a	0.122 ± 0.024^a	0.147 ± 0.022^a	0.114 ± 0.017^a
16	0.021 ± 0.003	0.055 ± 0.007^a	0.051 ± 0.012^a	0.053 ± 0.011^a	0.490 ± 0.007^a	0.046 ± 0.008^a	0.042 ± 0.004^a
17	0.036 ± 0.009	0.088 ± 0.015^a	0.079 ± 0.013^a	0.105 ± 0.009^a	0.0105 ± 0.025^a	0.102 ± 0.030^a	0.108 ± 0.015^a

The rats were exposed to three types of nanomaterials: SiO₂, Fe₃O₄, and SWCNTs. All the 17 spots have higher expression in the groups exposed to the three nanomaterials than in the control group (p < 0.05), and there is no significant difference between two doses of the same nanomaterial (p > 0.05). ^aCompared with the control group, p < 0.05.

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