Insulin-producing cells could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells

Table 4 Morphological features of three groups of cells

		Normal human pancreatic β cells	IPCs
Ra (nm)	N-glucose	107.05 ± 10.77	30.50 ± 1.61
	H-glucose (30 min)	135.05 ± 6.46*	41.88 ± 2.38*
	H-glucose (1 h)	138.26 ± 11.76*	49.41 ± 7.42*
	L-glucose (30 min)	115.81 ± 46.86*	30.76 ± 1.29
	L-glucose (1 h)	129.99 ± 15.33*	36.58 ± 2.99*
Particle size (nm)	N-glucose	215 ± 7.9	152 ± 5.7
	H-glucose (30 min)	345 ± 9.35*	225 ± 7.9*
	H-glucose (1 h)	360 ± 8.0*	233 ± 10.4*
	L-glucose (30 min)	221 ± 12.94*	160 ± 7.90
	L-glucose (1 h)	229 ± 14.74*	169 ± 9.62

*Compared with N-glucose, the difference was significant, P < 0.05. N, none; H, high; L, low.