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Figure 4 | Nanoscale Research Letters

Figure 4

From: ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes

Figure 4

Effect of ZnO NPs on intracellular ROS generation in cultured primary astrocytes. (A) ROS generation in astrocytes. Cells were treated with 4, 8, or 12 μg/ml of ZnO NPs for 6, 12, or 24 h, respectively. (B) Inhibitory effect of NAC on ROS generation. Astrocytes were pretreated for 1 h with 5 mM of NAC before 6 h of co-exposure with ZnO NPs (12 μg/ml). Data are presented as the mean ± SD of three representative experiments. **p < 0.01, ***p < 0.001 vs. control. #p < 0.05 vs. ZnO NPs (12 μg/ml).

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