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Figure 6 | Nanoscale Research Letters

Figure 6

From: Dendrimers: synthesis, applications, and properties

Figure 6

Requirements for dendrimer-based, cancer-targeted drug delivery. (A) Dendrimers with multiple surface functional groups can be directed to cancer cells by tumor-targeting entities that include folate or antibodies specific for tumor-associated antigens (TAAs). (B) The next step is ingestion into the cell which, in the case of folate targeting, occurs by membrane receptor-mediated endocytosis. (C) Once inside the cell, the drug generally must be released from the dendrimer, which, for the self-immolative method, results in the simultaneous disintegration of the dendritic scaffold (D).

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