Table 2 Advantages and disadvantages of non-viral vectors
From: A sight on the current nanoparticle-based gene delivery vectors
Type of nanoparticle | Advantages | Disadvantages | References |
|---|---|---|---|
Inorganic nanoparticles | Short time of transfection, easy preparation, wide availability, rich functionality, high transfection efficiency, potential capability for targeted delivery and controlled release | Most of them are instable, toxic and non-biocompatible | |
Polymer-based nanoparticles | Small size, narrow distribution, more stability, high protection against enzymatic degradation, low toxicity and high cationic potential | Low biodegradability, low efficacy | |
Lipid-based nanoparticles | Safe preparation, low immunogenicity, | Toxicity at high dose, difficult preparation, low transformation efficiency | [20] |
Hybrid nanoparticles | Improved the loading dose of DNA cellular uptake, controlling the release of the DNA and target delivery compared to other non-viral vectors | Toxicity at very high dose |