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Table 2 Advantages and disadvantages of non-viral vectors

From: A sight on the current nanoparticle-based gene delivery vectors

Type of nanoparticle Advantages Disadvantages References
Inorganic nanoparticles Short time of transfection, easy preparation, wide availability, rich functionality, high transfection efficiency, potential capability for targeted delivery and controlled release Most of them are instable, toxic and non-biocompatible [18, 48, 56]
Polymer-based nanoparticles Small size, narrow distribution, more stability, high protection against enzymatic degradation, low toxicity and high cationic potential Low biodegradability, low efficacy [25, 29, 31]
Lipid-based nanoparticles Safe preparation, low immunogenicity, Toxicity at high dose, difficult preparation, low transformation efficiency [20]
Hybrid nanoparticles Improved the loading dose of DNA cellular uptake, controlling the release of the DNA and target delivery compared to other non-viral vectors Toxicity at very high dose [25, 73]