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Table 1 Deprotection strategies

From: Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability

Deprotection strategy

Exposition time

Sample

NH3(l) @55°C

30 min; 1 h; 2 h

PSi-Ma-NH2

PSi-Mb-NH2

K2CO3/MeOH @55°C

30 min; 1 h; 2 h; 5 h; 8 h; overnight

PSi-Mc-NH2

PSi-Md-NH2

NH3(g) @RT

Overnight

PSi-Me-NH2

  

PSi-Mf-NH2

  

PSi-Mg-NH2-oligo

  

PSi-Mh-NH2-oligo

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