In vivo and in vitro evaluation of the cytotoxic effects of Photosan-loaded hollow silica nanoparticles on liver cancer

Table 2 Subcutaneous xenograft tumor volumes (cm ³ ) in nude mice

	Group A	Group B	Group C	P(A/B)	P(A/C)	P(B/C)
1.	15	15	15	-	-	-
2.	0.525 ± 0.019	0.520 ± 0.013	0.527 ± 0.015	0.588	0.876	0.487
3.	0.867 ± 0.031	0.250 ± 0.010*	0.412 ± 0.013*	0.000	0.000	0.856
4.	1.236 ± 0.039	0.112 ± 0.013*	0.217 ± 0.011*	0.000	0.000	0.770
5.	1.750 ± 0.169	0.035 ± 0.014*^#	0.105 ± 0.038*	0.000	0.000	0.020
6.	2.251 ± 0.162	0.114 ± 0.020*^#	0.406 ± 0.050*	0.000	0.000	0.001
7.	2.451 ± 0.397	0.266 ± 0.042*^#	0.608 ± 0.076*	0.000	0.000	0.008
8.	2.657 ± 0.411	0.475 ± 0.058*^#	1.058 ± 0.170*	0.000	0.000	0.004
9.	3.050 ± 0.438	0.623 ± 0.108*^#	1.551 ± 0.180*	0.000	0.000	0.000

1. Number of animals; 2. Before treatment; 3. 2 days after treatment; 4. 4 days after treatment; 5. 6 days after treatment; 6. 8 days after treatment; 7. 10 days after treatment; 8. 12 days after treatment; 9. 14 days after treatment; Group A - blank control; Group B - nanoscale Photosan group; Group C - conventional Photosan group; P(A/B) - P value for comparing group A and group B; P(A/C) - P value for comparing group A and group C; P(B/C) - P value for comparing group B and group C. *Significantly different (P < 0.05) from group A, ^#Significantly different (P < 0.05) from group C.