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Figure 4 | Nanoscale Research Letters

Figure 4

From: Validation of a Janus role of methotrexate-based PEGylated chitosan nanoparticles in vitro

Figure 4

Physicochemical characterization of the (MTX + PEG)-CS-NPs. (A) Particle size of the CS-NPs, PEG-CS-NPs, and (MTX + PEG)-CS-NPs (mean ± SD, n = 3). (B) Zeta potential of the CS-NPs, PEG-CS-NPs, and (MTX + PEG)-CS-NPs (mean ± SD, n = 3). (C) AFM image of the (MTX + PEG)-CS-NPs. Scale bars = 500 nm. Inset: TEM image of the (MTX + PEG)-CS-NPs. Scale bars = 50 nm. (D) Particle size distribution of the (MTX + PEG)-CS-NPs. (E) Zeta potential distribution of the (MTX + PEG)-CS-NPs. (F) In vitro stability tests of the (MTX + PEG)-CS-NPs in PBS (mean ± SD, n = 3). (G) In vitro stability tests of the (MTX + PEG)-CS-NPs in 10% plasma in PBS (mean ± SD, n = 3).

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