Carbon nanotubes: properties, synthesis, purification, and medical applications
© Eatemadi et al.; licensee Springer. 2014
Received: 29 April 2014
Accepted: 27 June 2014
Published: 13 August 2014
Current discoveries of different forms of carbon nanostructures have motivated research on their applications in various fields. They hold promise for applications in medicine, gene, and drug delivery areas. Many different production methods for carbon nanotubes (CNTs) have been introduced; functionalization, filling, doping, and chemical modification have been achieved, and characterization, separation, and manipulation of individual CNTs are now possible. Parameters such as structure, surface area, surface charge, size distribution, surface chemistry, and agglomeration state as well as purity of the samples have considerable impact on the reactivity of carbon nanotubes. Otherwise, the strength and flexibility of carbon nanotubes make them of potential use in controlling other nanoscale structures, which suggests they will have a significant role in nanotechnology engineering.
Carbon nanotubes: structure and properties
Carbon can bond in different ways to construct structures with completely different properties. The sp2 hybridization of carbon builds a layered construction with weak out-of-plane bonding of the van der Waals form and strong in-plane bounds. A few to a few tens of concentric cylinders with the regular periodic interlayer spacing locate around ordinary central hollow and made MWCNTs. The real-space analysis of multiwall nanotube images has shown a range of interlayer spacing (0.34 to 0.39 nm) .
Depending on the number of layers, the inner diameter of MWCNTs diverges from 0.4 nm up to a few nanometers and outer diameter varies characteristically from 2 nm up to 20 to 30 nm. Both tips of MWCNT usually have closed and the ends are capped by dome-shaped half-fullerene molecules (pentagonal defects), and axial size differs from 1 μm up to a few centimeter. The role of the half-fullerene molecules (pentagonal ring defect) is to help in closing of the tube at the two ends.
On other hand, SWCNT diameters differ from 0.4 to 2 to 3 nm, and their length is typically of the micrometer range. SWCNTs usually can come together and form bundles (ropes). In a bundle structure, SWCNTs are hexagonally organized to form a crystal-like construction .
MWCNT and SWCNT structure
where corresponds to the lattice constant in the graphite sheet.
When n − m is a multiple of 3, then the nanotube is described as ‘metallic’ or highly conducting nanotubes, and if not, then the nanotube is a semimetallic or semiconductor.
At all times, the armchair form is metallic, whereas other forms can make the nanotube a semiconductor.
Translational vector = T = t 1a 1 + t 2a 2 » (t 1, t 2)
Chiral vector = Ch = na 1 + na 2 » (n, m)
Length of chiral vector = L = a √ (n2 + m2 + n * m), where a is the lattice constant
Chiral angle = cosθ = (2n + m)/(2 * √ (n2 + m2 + n * m))
Number of hexagons in the unit cell = N = (2 * (n2 + m2 + n * m)/dR)
Diameter = dt = L/π
Rotation angle of the symmetry vector = ψ = 2π/N (in radians)
Symmetry vector = R = pa 1 + qa 2 » (p, q)
Pitch of the symmetry vector = τ = ((m * p–n * q) * T)/N
Comparison between SWNT and MWNT
Single layer of graphene
Multiple layers of graphene
Catalyst is required for synthesis
Can be produced without catalyst
Bulk synthesis is difficult as it requires proper control over growth and atmospheric condition
Bulk synthesis is easy
Purity is poor
Purity is high
A chance of defect is more during functionalization
A chance of defect is less but once occurred it is difficult to improve
Less accumulation in the body
More accumulation in the body
Characterization and evaluation is easy
It has very complex structure
It can be easily twisted and is more pliable
It cannot be easily twisted
Since carbon nanotubes have the sp2 bonds between the individual carbon atoms, they have a higher tensile strength than steel and Kevlar. This bond is even stronger than the sp3 bond found in diamond. Theoretically, SWCNTs may really have a tensile strength hundreds of times stronger than steel.
Another amazing property of carbon nanotubes is also elasticity. Under high force and press sitting and when exposed to great axial compressive forces, it can bend, twist, kink, and finally buckle without damaging the nanotube, and the nanotube will return to its original structure, but an elasticity of nanotubes does have a limit, and under very physically powerful forces presses, it is possible to temporarily deform to shape of a nanotube. Some of the defects in the structure of the nanotube can weaken a nanotube's strength, for example, defects in atomic vacancies or a rearrangement of the carbon bonds.
The physical properties of carbon nanotubes
Average diameter of SWNTs
1.2 to 1.4 nm
Distance from opposite carbon atoms (line 1)
Analogous carbon atom separation (line 2)
Parallel carbon bond separation (line 3)
Carbon bond length (line 4)
C-C tight bonding overlap energy
Approximately 2.5 eV
Group symmetry (10, 10)
Lattice: bundles of ropes of nanotubes
Triangular lattice (2D)
(10, 10) Armchair
(17, 0) Zigzag
(12, 6) Chiral
(10, 10) Armchair
(17, 0) Zigzag
(12, 6) Chiral
(n, n) Armchair
(n, 0) Zigzag
(2n, n) Chiral
For (n, m); n − m is divisible by 3 [metallic]
For (n, m); n − m is not divisible by 3 [semiconducting]
Approximately 0.5 eV
(12.9 k O )-1
10-4 O -cm
Maximum current density
Approximately 2,000 W/m/K
Phonon mean free path
Approximately 100 nm
Approximately 10 to 11 s
Young's modulus (SWNT)
Approximately 1 TPa
Young's modulus (MWNT)
Maximum tensile strength
Approximately 100 GPa
Summary and comparison of three most common CNT synthesis methods
SWNT or MWNT
Simple, inexpensive, high-quality nanotubes
Relatively high purity, room-temperature synthesis
Simple, low temperature, high purity, large-scale production, aligned growth possible
High temperature, purification required, tangled nanotubes
Method limited to the labscale, crude product purification required
Synthesized CNTs are usually MWNTs, defects
Electric arc discharge
Arc-discharge technique uses higher temperatures (above 1,700°C) for CNT synthesis which typically causes the expansion of CNTs with fewer structural defects in comparison with other methods. The most utilized methods use arc discharge between high-purity graphite (6 to 10-mm optical density (OD)) electrodes usually water-cooled electrodes with diameters between 6 and 12 mm and separated by 1 to 2 mm in a chamber filled with helium (500 torr) at subatmospheric pressure (helium can be replaced by hydrogen or methane atmosphere) . The chamber contains a graphite cathode and anode as well as evaporated carbon molecules and some amount of metal catalyst particles (such as cobalt, nickel, and/or iron). Direct current is passed through the camber (arcing process), and the chamber is pressurized and heated to approximately 4,000 K. In the course of this procedure and arcing, about half of the evaporated carbon solidifies on the cathode (negative electrode) tip, and a deposit forms at a rate of 1 mm/min which is called ‘cylindrical hard deposit or cigar-like structure’, whereas the anode (positive electrode) is consumed. The remaining carbon (a hard gray shell) deposited on the periphery and condenses into ‘chamber soot’ nearby the walls of the chamber and ‘cathode soot’ on the cathode. The inner core, cathode soot and chamber soot, which are dark and soft, yield either single-walled or multiwalled carbon nanotubes and nested polyhedral graphene particles. By using scanning electron microscopy (SEM), two different textures and morphologies can be observed in studying of the cathode deposit; the dark and soft inner core deposits consist of bundle-like structures, which contain randomly arranged nanotubes and the gray outer shell, which is composed of curved and solid grapheme layers.
In the arc discharge deposition and synthesis of CNTs, there are two main different ways: synthesis with use of different catalyst precursors and without use of catalyst precursors. Generally, synthesis of MWNTs could be done without use of catalyst precursors but synthesis of single-wall nanotubes (SWNTs) utilizes different catalyst precursors and, for expansion in arc discharge, utilizes a complex anode, which is made as a composition of graphite and a metal, for example, Gd , Co, Ni, Fe, Ag, Pt, Pd, etc., or mixtures of Co, Ni, and Fe with other elements like Co-Pt, Co-Ru , Ni-Y, Fe-Ni, Co-Ni, Co-Cu, Ni-Cu, Fe-No, Ni-Ti, Ni-Y, etc. Studies have shown Ni-Y-graphite mixtures can produce high yields (<90%) of SWNTs (average diameter of 1.4 nm) , and nowadays, this mixture is used worldwide for creation of SWNTs in high yield. The main advantage of arc-discharge technique is ability and potential for production of a large quantity of nanotubes. On the other hand, the main disadvantage of this method is relatively little control over the alignment (i.e., chirality) of the created nanotubes, which is important for their characterization and role. Additionally, because of the metallic catalyst needed for the reaction, purification of the obtained products is essential.
Laser ablation method
By using of high-power laser vaporization (YAG type), a quartz tube containing a block of pure graphite is heated inside a furnace at 1,200 ± C, in an Ar atmosphere . The aim of using laser is vaporizing the graphite within the quartz. As described about the synthesis of SWNT by using arc-discharge method, for generating of SWNTs, using the laser technique adding of metal particles as catalysts to the graphite targets is necessary. Studies have shown the diameter of the nanotubes depends upon the laser power. When the laser pulse power is increased, the diameter of the tubes became thinner . Other studies have indicated ultrafast (subpicosecond) laser pulses are potential and able to create large amounts of SWNTs . The authors revealed that it is now promising to create up to 1.5 g/h of nanotube material using the laser technique.
Many parameters can affect the properties of CNTs synthesized by the laser ablation method such as the structural and chemical composition of the target material, the laser properties (peak power, cw versus pulse, energy fluence, oscillation wavelength, and repetition rate), flow and pressure of the buffer gas, the chamber pressure and the chemical composition, the distance between the target and the substrates, and ambient temperature. This method has a potential for production of SWNTs with high purity and high quality. The principles and mechanisms of laser ablation method are similar to the arc-discharge technique, but in this method, the needed energy is provided by a laser which hit a pure graphite pellet holding catalyst materials (frequently cobalt or nickel).
The main advantages of this technique consist of a relatively high yield and relatively low metallic impurities, since the metallic atoms involved have a tendency to evaporate from the end of the tube once it is closed. On other hand, the main disadvantage is that the obtained nanotubes from this technique are not necessarily uniformly straight but instead do contain some branching.
Unfortunately, the laser ablation method is not economically advantageous because the procedure encompasses high-purity graphite rods, the laser powers required are great (in some cases two laser beams are required), and the quantity of nanotubes that can be synthesized per day is not as high as arc-discharge technique.
Chemical vapor deposition
One of standard methods for production of carbon nanotubes is chemical vapor deposition or CVD. There are many different types of CVD such as catalytic chemical vapor deposition (CCVD)—either thermal  or plasma enhanced (PE) oxygen assisted CVD , water assisted CVD [21–23], microwave plasma (MPECVD) , radiofrequency CVD (RF-CVD) , or hot-filament (HFCVD) [26, 27]. But catalytic chemical vapor deposition (CCVD) is currently the standard technique for the synthesis of carbon nanotubes.
This technique allows CNTs to expand on different of materials and involves the chemical breakdown of a hydrocarbon on a substrate. The main process of growing carbon nanotubes in this method as same as arc-discharge method also is exciting carbon atoms that are in contact with metallic catalyst particles.
For all intents and purposes, tubes are drilled into silicon and also implanted with iron nanoparticles at the bottom. After that, a hydrocarbon such as acetylene is heated and decomposed onto the substrate. Since the carbon is able to make contact with the metal particles implanted in the holes, it initiates to create nanotubes which are a ‘template’ from the shape of the tunnel. With using of these properties, the carbon nanotubes can grow very well aligned and very long, in the angle of the tunnel. In CVD processing, a layer of metal catalyst particles prepare and process a substrate at approximately 700°C. Most commonly, metal catalyst particles are nickel, cobalt , iron, or a combination . The aim of using the metal nanoparticles in combination with a catalyst support such as MgO or Al2O3 is to develop the surface area for higher by-product of the catalytic reaction of the pure carbon with the metal particles. In the first step of nanotube expansion, two types of gases fueled the reactor (the most widely used reactor is fluidized bed reactor [30, 31]): a carbon-containing gas (such as ethylene, acetylene, methane, or ethanol) and a process gas (such as nitrogen, hydrogen, or ammonia). At the surface of the catalyst particle, the carbon-containing gas is broken apart and so the carbon became visible at the edges of the nanoparticle where the nanotubes can produce. This mechanism is still under discussion . Studies have shown the conventionally accepted models are base growth and tip growth . Depending on the adhesion and attachment between the substrate and the catalyst particle, the catalyst particles can remain at the nanotube base or nanotube during growth and expansion .
As compared with laser ablation, CCVD is an economically practical method for large-scale and quite pure CNT production and so the important advantage of CVD are high purity obtained material and easy control of the reaction course .
Depending on technique of carbon nanotube synthesis, there are many different methods and procedure for purification. All purification procedures have the following main steps: deletion of large graphite particles and aggregations with filtration, dissolution in appropriate solvents to eliminate catalyst particles (concentrated acids as solvent) and fullerenes (use of organic solvents), and microfiltrations and chromatography to size separation and remove the amorphous carbon clusters . Purification of MWNTs produced by arc-discharge techniques can be done by using oxidation techniques which can take apart MWNTs from polyhedral graphite-like particles .
The main disadvantages of this method are low purity, high destroying rate of starting materials (95%), as well as high reactivity of the remaining nanotubes at end of process due to existence of dangling bonds (an unsatisfied valence)  and for elimination of such dangling bonds is necessary to use high-temperature annealing (2,800 ± C).
The nondestructive methods for separating CNTs couple well-dispersed colloidal suspensions of tubes/particles with materials which prevent aggregation such as surfactants, polymers, or other colloidal particles . The other method as aim of size exclusion nanotubes uses size exclusion chromatography and porous filters  as well as ultrasonically assisted microfiltration which purifies SWNTs from amorphous carbon and catalytic particles .
Studies have shown the boiling of SWNTs in nitric acid  or hydrofluoric acid  aqueous solutions for purification of SWNTs and removing amorphous carbon and metal particles as an efficient and simple technique.
For the purification of carbon tubules, scientist prefers to use sonication of nanotube in different media and afterward thermal oxidation of SWNT material (at 470°C) as well as hydrochloric acid treatments . Another way for oxidizing unsatisfied carbonaceous particles is use of gold clusters (OD 20 nm) together with the thermal oxidation of SWNTs at 350°C .
Huang et al. introduce a new way for separation of semiconducting and metallic SWNTs by using of size exclusion chromatography (SEC) of DNA-dispersed carbon nanotubes (DNA-SWNT), which have the highest resolution length sorting . The density-gradient ultracentrifugation has been used for separation of SWNT based on diameter . Combination of ion-exchange chromatography (IEC) and DNA-SWNT (IEC-DNA-SWNT) has also been used for purification of individual chiralities. In this process, specific short DNA oligomers can be used to separate individual SWNT chiralities. Scientists have used fluorination and bromination processes as well as acid treatments of MWNT and SWNT material with the aims of purifying, cutting, and suspending the materials uniformly in certain organic solvents [45, 46].
As discussed above, depending on nanotube synthesis way, there are many different methods for purification of carbon nanotubes, and therefore, existence of methods which are single-step processes and unaffected on properties of carbon nanotube products is essential for producing clean nanotubes and should be targeted in the future.
The properties of nanotubes are certainly amazing; in the last few years, many studies have suggested potential applications of CNTs and have shown innumerable applications that could be promising when these newly determined materials are combined with typical products [36, 47–51]. Production of nanorods using CNTs as reacting templates [51–55].
Applications for nanotubes encompass many fields and disciplines such as medicine, nanotechnology, manufacturing, construction, electronics, and so on. The following application can be noted: high-strength composites [54, 56–61], actuators , energy storage and energy conversion devices , nanoprobes and sensors , hydrogen storage media , electronic devices , and catalysis . However, the following sections detail existing applications of CNTs in the biomedical industry exclusively. Before use of carbon nanotube in biological and biomedical environments, there are three barriers which must be overcome: functionalization, pharmacology, and toxicity of CNTs. One of the main disadvantages of carbon nanotubes is the lack of solubility in aqueous media, and to overcome this problem, scientists have been modifying the surface of CNTs, i.e., fictionalization with different hydrophilic molecules and chemistries that improve the water solubility and biocompatibility of CNT .
Another barrier with carbon nanotube is the biodistribution and pharmacokinetics of nanoparticles which are affected by many physicochemical characteristics such as shape, size, chemical composition, aggregation, solubility surface, and fictionalization. Studies have shown that water-soluble CNTs are biocompatible with the body fluids and do not any toxic side effects or mortality.
Another important barrier is toxicity of CNTs. Generally, the combination of the high surface area and the intrinsic toxicity of the surface can be responsible for the harmful effects of nanoparticles.
The toxicity of CNTs can be affected by the size of nanotubes. The particles under 100 nm have potential harmful properties such as more potential toxicity to the lung, escape from the normal phagocytic defenses, modification of protein structure, activation of inflammatory and immunological responses, and potential redistribution from their site of deposition.
Nanomaterials show probability and promise in regenerative medicine because of their attractive chemical and physical properties . Generally, reject implants with the postadministration pain, and to avoid this rejection, attachment of nanotubes with proteins and amino acids has been promising. Carbon nanotube, both single and multi-WNT, can be employed as implants in the form of artificial joints and other implants without host rejection response. Moreover, because of unique properties such as high tensile strength, CNTs can act as bone substitutes and implants if filled with calcium and shaped/arranged in the bone structure [69, 70].
Application of nanotube as artificial implants
Natural or synthetic materials type
Cell or tissue type
Increase lamellipodia (cytoskeletal) extensions, and lamellipodia extensions
C2Cl2 cells /C2 myogenic cell line
Cell growth improvement
Collagen sponge honeycomb scaffold
MC3T3-E1 cells, a mouse osteoblast-like cell line
Increase cellular adhesion and proliferation
Enhance interactions between the cells and the polyurethane surface
Rat heart endothelial cell
Enhance cellular adhesion and proliferation
Human embryonic stem cells
Increase cellular differentiation toward neurons
Support cell attachment and proliferation
The aim of tissue engineering is to substitute damaged or diseased tissue with biologic alternates that can repair and preserve normal and original function. Major advances in the areas of material science and engineering have supported in the promising progress of tissue regenerative medicine and engineering. Carbon nanotubes can be used for tissue engineering in four areas: sensing cellular behavior, cell tracking and labeling, enhancing tissue matrices, and augmenting cellular behavior . Cell tracking and labeling is the ability to track implanted cells and to observe the improvement of tissue formation in vivo and noninvasively. Labeling of implanted cells not only facilitates evaluating of the viability of the engineered tissue but also assists and facilitates understanding of the biodistribution, migration, relocation, and movement pathways of transplanted cells. Because of time consuming and challenge of handling in using of traditional methods such as flow cytometry, noninvasive methods are incoming popular methods. It is shown carbon nanotubes can be feasible as imaging contrast agents for magnetic resonance, optical, and radiotracer modalities.
Another important application of carbon nanotubes in tissue engineering is its potential for measure of biodistribution and can also be modified with radiotracers for gamma scintigraphy. Singh et al. bound SWNTs with . In and administered to BALB/c mice to evaluate the biodistribution of nanotubes . The design of better engineered tissues enhances and facilitates with the better monitor of cellular physiology such as enzyme/cofactor interactions, protein and metabolite secretion, cellular behavior, and ion transport. Nanosensors possibly will be utilized to make available constant monitoring of the performance of the engineered tissues. Carbon nanotubes present numerous popular features that make them ideal elements for nanosensors including their large surface area and capacity to immobilize DNA or other proteins, and electrical properties. The carbon nanotube has unique electronic structures which as carbon nanotube electrochemical sensor probability makes simpler the investigation of redox-active proteins and amino acids allowing cell monitoring in engineered tissues. In one study, MWNTs were conjugated with platinum microparticles and were able to sense thiols including amino acids such as glutathione and L-cysteine in rat .
The matrix of cells plays an important role in tissue engineering. While accepted synthetic polymers, for example, PLGA and PLA have been employed for tissue engineering, they lack the required mechanical strength and cannot simply be functionalized in contradiction of carbon nanotubes which can be voluntarily functionalized. Thus, carbon nanotubes have potential for use as tissue scaffolds and can provide the required structural reinforcement, but the main disadvantage of carbon nanotubes is that they are not biodegradable. Combination of polymer by dissolving a desired portion of carbon nanotubes into a polymer, significant enhancements in the mechanical strength of the composite has been detected. MWNTs combined with chitosan illustrated significant advancement in mechanical properties compared with only chitosan . The SWNT blended collagen improves smooth muscle cell growth [83–89].
Cancer cell identification
Nanodevices are being created that have a potential to develop cancer treatment, detection, and diagnosis. Nanostructures can be so small (less than 100 nm) that the body possibly will clear them too quickly for them to be efficient in imaging or detection and so can enter cells and the organelles inside them to interact with DNA and proteins. Castillo et al., by using a peptide nanotube-folic acid modified graphene electrode, improve detection of human cervical cancer cells overexpressing folate receptors [90–96].
Since a large amount of cancers are asymptomatic throughout their early stage and distinct morphologic modifications are absent in the majority of neoplastic disorders in early stage, consequently traditional clinical cancer imaging methods, for example, X-ray, CT, and MRI, do not acquire adequate spatial resolution for detection of the disease in early stage. The imaging studies with SWCNTs have thrived over the past few years. Hong et al.  evaluated the molecular imaging with SWNTs and evaluated the combined Gd3 + -functionalized SWCNTs when applied to MRI, and high resolution and good tissue penetration were achieved.
Combination of radioisotopes labeled SWCNTs with radionuclide based imaging techniques (PET and SPECT) can improve the tissue penetration, sensitivity, and medium resolution.
Example of detection of cancer biomarker by carbon nanotubes
Form of cancer
P-type carbon nanotubes
Prostate-specific antigen (PSA)
Multilabel secondary antibody-nanotube bioconjugates
Prostate-specific antigen (PSA)
Microelectrode arrays modified with single-walled carbon nanotubes (SWNTs)
Total prostate-specific antigen (T-PSA)
Multiwalled carbon nanotubes-thionine-chitosan (MWCNTs-THI-CHIT) nanocomposite film
Carcinoma antigen-125 (CA125)
MWCNT-platinum nanoparticle-doped chitosan (CHIT)
Poly-l-lysine/hydroxyapatite/carbon nanotube (PLL/HA/CNT) hybrid nanoparticles
Carbohydrate antigen 19–9 (CA19-9)
MWCN-polysulfone (PSf) polymer
Human chorionic gonadotropin (hCG)
Multiwalled carbon nanotube-chitosan matrix
Human chorionic gonadotropin (hCG)
MWCNT-glassy carbon electrode (GCE)
Prostate-specific antigen (PSA)
Nanoparticle (NP) label/immunochromatographic electrochemical biosensor
Prostate-specific antigen (PSA)
SWNT-horseradish peroxidase (HRP)
Prostate-specific antigen (PSA)
Carbon nanotube field effect transistor (CNT-FET)
Prostate-specific antigen (PSA)
Carbon nanoparticle (CNP)/poly(ethylene imine) (PEI)-modified screen-printed graphite electrode (CNP-PEI/SPGE)
Carcinoembryonic antigen (CEA),
Tris(2,2′-bipyridyl)cobalt(III) (Co(bpy)33+)- MWNTs-Nafion composite film
Carcinoma antigen-125 (CA125)
Gold nanoparticles and carbon nanotubes doped chitosan (GNP/CNT/Ch) film
Multiple enzyme layers assembled multiwall carbon nanotubes (MWCNTs)
Drug and gene delivery by CNTs
Example of drugs and nucleic acids which were delivered by carbon nanotubes
Cell or tissue
High potency toward specific cancer cell lines
Efficiently taken up by cancer cells, then translocates to the nucleus while the nanotubes remain in the cytoplasm
Rapid regression of tumor growth
Nasopharyngeal epidermoid carcinoma, etc.
High and specific binding to the folate receptor (FR) for the SWNT-1 conjugate
Breast cancer Glioblastoma
Show that large surface areas on single-walled carbon nanotubes (SWNTs)
Increase nuclear DNA damage and inhibit the cell proliferation
The selective targeting of tumor in vitro and in vivo
High treatment efficacy, minimum side effects
Tumor cells both in vitro and in vivo mouse models
Increase suppression of tumor growth
Toxic siRNA sequence (siTOX)
Human lung xenograft model
Significant tumor growth inhibition
Enhance the efficiency of siRNA-mediated gastrin-releasing peptide receptor (GRP-R) gene silencing
Dendritic cells (DCs)
Reduced SOCS1 expression and retarded the growth of established B16 tumor in mice
Nanomaterials explain probability and promise in regenerative medicine for the reason that of their attractive chemical and physical properties.
Carbon nanotubes (purified/modified) have a high potential of finding unique applications in wide areas of medicine. Moreover, the encapsulation of other materials in the carbon nanotubes would open up a prospect for their bioapplications in medicine.
There remains amount of essential issues that require to be resolved, on the other hand, such as homogeneity of the material that contains wide distribution of the nanotube's diameters, unlike nanostructures, presence of residual metals; division of the individual nanotubes; and a sensitivity to the different gases and species [126–139].
The authors thank the Department of Medical Nanotechnology, and Biotechnology Faculty of Advanced Medical Science of Tabriz University for all supports provided. This work is funded by the Grant 2011-0014246 of the National Research Foundation of Korea.
- Ouyang M, Huang JL, Cheung CL, Lieber CM: Atomically resolved single-walled carbon nanotube intramolecular junctions. Science 2001, 291(5501):97–100.Google Scholar
- Kim H, Lee J, Kahng SJ, Son YW, Lee SB, Lee CK, Ihm J, Kuk Y: Direct observation of localized defect states in semiconductor nanotube junctions. Phys Rev Lett 2003, 90(21):216107.Google Scholar
- Chico L, Crespi VH, Benedict LX, Louie SG, Cohen ML: Pure carbon nanoscale devices: nanotube heterojunctions. Phys Rev Lett 1996, 76(6):971–974.Google Scholar
- Iijima S, Ichihashi T: Single-shell carbon nanotubes of 1-nm diameter. 1993.Google Scholar
- Iijima S: Helical microtubules of graphitic carbon. Nature 1991, 354(6348):56–58.Google Scholar
- Schematic structure of SWNT. 2014. Ref Type: Generic Ref Type: GenericGoogle Scholar
- The transmission electron microscope (TEM) images of a SWNT. 2014. Ref Type: Online Source Ref Type: Online SourceGoogle Scholar
- The transmission electron microscope (TEM) images of a MWNT. 2014. Ref Type: Online Source Ref Type: Online SourceGoogle Scholar
- Ajayan PM, Ebbesen TW: Nanometre-size tubes of carbon. Rep Prog Phys 1997, 60(10):1025.Google Scholar
- Grobert N: Carbon nanotubes—becoming clean. Mater Today 2007, 10(1):28–35.Google Scholar
- WanderWal RL: Carbon nanotube synthesis in a flame using laser ablation for in situ catalyst generation. 2003, 77(7):885–889. Ref Type: GenericGoogle Scholar
- Abbasi E, Sedigheh Fekri A, Abolfazl A, Morteza M, Hamid Tayefi N, Younes H, Kazem N-K, Roghiyeh P-A: Dendrimers: synthesis, applications, and properties. Nanoscale Research Letters 2014, 9(1):247–255.Google Scholar
- Jose-Yacaman M, Miki-Yoshida M, Rendon L, Santiesteban JG: Catalytic growth of carbon microtubules with fullerene structure. Appl Phys Lett 1993, 62(2):202–204.Google Scholar
- Thess A, Lee R, Nikolaev P, Dai H, Petit P, Robert J, Xu C, Lee YH, Kim SG, Rinzler AG: Crystalline ropes of metallic carbon nanotubes. Science-AAAS-Weekly Paper Edition 1996, 273(5274):483–487.Google Scholar
- Hirlekar R, Yamagar M, Garse H, Vij M, Kadam V: Carbon nanotubes and its applications: a review. Asian J Pharmaceut Clin Res 2009, 2(4):17–27.Google Scholar
- Hou PX, Bai S, Yang QH, Liu C, Cheng HM: Multi-step purification of carbon nanotubes. Carbon 2002, 40(1):81–85.Google Scholar
- Ganesh EN: Single Walled and Multi Walled Carbon Nanotube Structure. Synthesis and Applications 2013, 2(4):311–318.Google Scholar
- Askeland DR, Phul PP: The science and engineering of materials. 2003.Google Scholar
- Saito R, Dresselhaus G, Dresselhaus MS: Physical properties of carbon nanotubes. 4th edition. USA: World Scientific; 1998.Google Scholar
- Vander Wal RL, Berger GM, Ticich TM: Carbon nanotube synthesis in a flame using laser ablation for in situ catalyst generation. Applied Physics A 2003, 77(7):885–889.Google Scholar
- Iijima S, Ajayan PM, Ichihashi T: Growth model for carbon nanotubes. Phys Rev Lett 1992, 69(21):3100.Google Scholar
- Journet C, Maser WK, Bernier P, Loiseau A, De La Chapelle ML, Lefrant D, Deniard P, Lee R, Fischer JE: Large-scale production of single-walled carbon nanotubes by the electric-arc technique. Nature 1997, 388(6644):756–758.Google Scholar
- He ZB, Maurice JL, Lee CS, Cojocaru CS, Pribat D: Nickel catalyst faceting in plasma-enhanced direct current chemical vapor deposition of carbon nanofibers. The Arabian Journal for Science and Engineering 2010, 35(1C):11–19.Google Scholar
- Ebbesen TW, Ajayan PM: Large-scale synthesis of carbon nanotubes. Nature 1992, 358(6383):220–222.Google Scholar
- Bernholc J, Roland C, Yakobson BI: Nanotubes. Curr Opinion Solid State Mater Sci 1997, 2(6):706–715.Google Scholar
- Dervishi E, Li Z, Xu Y, Saini V, Biris AR, Lupu D, Biris AS: Carbon nanotubes: synthesis, properties, and applications. Part Sci Technol 2009, 27(2):107–125.Google Scholar
- Ajayan PM, Charlier JC, Rinzler AG: Carbon nanotubes: from macromolecules to nanotechnology. Proc Natl Acad Sci 1999, 96(25):14199–14200.Google Scholar
- Terrones M: Production and characterization of novel fullerene related materials: nanotubes, nanofibres and giant fullerenes. 1997.Google Scholar
- Landi BJ, Raffaelle RP, Castro SL, Bailey SG: Single-wall carbon nanotube—polymer solar cells. Prog Photovolt Res Appl 2005, 13(2):165–172.Google Scholar
- Eklund PC, Pradhan BK, Kim UJ, Xiong Q, Fischer JE, Friedman AD, Holloway BC, Jordan K, Smith MW: Large-scale production of single-walled carbon nanotubes using ultrafast pulses from a free electron laser. Nano Lett 2002, 2(6):561–566.Google Scholar
- Steiner SA, Baumann TF, Bayer BC, Blume R, Worsley MA, MoberlyChan WJ, Shaw EL: Nanoscale zirconia as a nonmetallic catalyst for graphitization of carbon and growth of single- and multiwall carbon nanotubes. J Am Chem Soc 2009, 131(34):12144–12154.Google Scholar
- Choudhary N, Hwang S, Choi W: Carbon nanomaterials: a review. In Handbook of Nanomaterials Properties. USA: Springer; 2014:709.Google Scholar
- Tempel H, Joshi R, Schneider JJ: Ink jet printing of ferritin as method for selective catalyst patterning and growth of multiwalled carbon nanotubes. Mater Chem Phys 2010, 121(1):178–183.Google Scholar
- Smajda R, Andresen JC, Duchamp M, Meunier R, Casimirius S, Hernadi K, Forr+¦ L, Magrez A: Synthesis and mechanical properties of carbon nanotubes produced by the water assisted CVD process. Physica status solidi (b) 2009, 246(11–12):2457–2460.Google Scholar
- Patole SP, Alegaonkar PS, Lee HC, Yoo JB: Optimization of water assisted chemical vapor deposition parameters for super growth of carbon nanotubes. Carbon 2008, 46(14):1987–1993.Google Scholar
- Banerjee S, Naha S, Puri IK: Molecular simulation of the carbon nanotube growth mode during catalytic synthesis. Appl Phys Lett 2008, 92(23):233121.Google Scholar
- Brown B, Parker CB, Stoner BR, Glass JT: Growth of vertically aligned bamboo-like carbon nanotubes from ammonia/methane precursors using a platinum catalyst. Carbon 2011, 49(1):266–274.Google Scholar
- Xu Y, Dervishi E, Biris AR, Biris AS: Chirality-enriched semiconducting carbon nanotubes synthesized on high surface area MgO-supported catalyst. Mater Lett 2011, 65(12):1878–1881.Google Scholar
- Prasek J, Drbohlavova J, Chomoucka J, Hubalek J, Jasek O, Adam V, Kizek R: Methods for carbon nanotubes synthesis—review. J Mater Chem 2011, 21(40):15872–15884.Google Scholar
- Varshney D, Weiner BR, Morell G: Growth and field emission study of a monolithic carbon nanotube/diamond composite. Carbon 2010, 48(12):3353–3358.Google Scholar
- Inami N, Ambri Mohamed M, Shikoh E, Fujiwara A: Synthesis-condition dependence of carbon nanotube growth by alcohol catalytic chemical vapor deposition method. Sci Technol Adv Mater 2007, 8(4):292–295.Google Scholar
- Ishigami N, Ago H, Imamoto K, Tsuji M, Iakoubovskii K, Minami N: Crystal plane dependent growth of aligned single-walled carbon nanotubes on sapphire. J Am Chem Soc 2008, 130(30):9918–9924.Google Scholar
- Pinilla JL, Moliner R, Suelves I, Lízaro MJ, Echegoyen Y, Palacios JM: Production of hydrogen and carbon nanofibers by thermal decomposition of methane using metal catalysts in a fluidized bed reactor. Int J Hydrog Energy 2007, 32(18):4821–4829.Google Scholar
- Muradov N: Hydrogen via methane decomposition: an application for decarbonization of fossil fuels. Int J Hydrog Energy 2001, 26(11):1165–1175.Google Scholar
- Naha S, Puri IK: A model for catalytic growth of carbon nanotubes. J Phys D Appl Phys 2008, 41(6):065304.Google Scholar
- Fotopoulos N, Xanthakis JP: A molecular level model for the nucleation of a single-wall carbon nanotube cap over a transition metal catalytic particle. Diam Relat Mater 2010, 19(5):557–561.Google Scholar
- Rao CNR, Cheetham AK: The Chemistry of Nanomaterials: Synthesis, Properties and Applications. 1st edition. Oxford University: John Wiley & Sons; 2006.Google Scholar
- Duesberg GS, Burghard M, Muster J, Philipp G: Separation of carbon nanotubes by size exclusion chromatography. Chem Commun 1998, 3: 435–436.Google Scholar
- Shelimov KB, Esenaliev RO, Rinzler AG, Huffman CB, Smalley RE: Purification of single-wall carbon nanotubes by ultrasonically assisted filtration. Chem Phys Lett 1998, 282(5):429–434.Google Scholar
- Krishnan A, Dujardin E, Ebbesen TW, Yianilos PN, Treacy MMJ: Young's modulus of single-walled nanotubes. Phys Rev B 1998, 58(20):14013.Google Scholar
- Fonseca A, Hernadi K, Piedigrosso P, Colomer JF, Mukhopadhyay K, Doome R, Lazarescu S, Biro LP, Lambin P, Thiry PA: Synthesis of single- and multi-wall carbon nanotubes over supported catalysts. Applied Physics A 1998, 67(1):11–22.Google Scholar
- Hou P, Liu C, Tong Y, Xu S, Liu M, Cheng H: Purification of single-walled carbon nanotubes synthesized by the hydrogen arc-discharge method. J Mater Res 2001, 16(09):2526–2529.Google Scholar
- Mizoguti E, Nihey F, Yudasaka M, Iijima S, Ichihashi T, Nakamura K: Purification of single-wall carbon nanotubes by using ultrafine gold particles. Chem Phys Lett 2000, 321(3):297–301.Google Scholar
- Huang X, Mclean RS, Zheng M: High-resolution length sorting and purification of DNA-wrapped carbon nanotubes by size-exclusion chromatography. Anal Chem 2005, 77(19):6225–6228.Google Scholar
- Hersam MC: Progress towards monodisperse single-walled carbon nanotubes. Nat Nanotechnol 2008, 3(7):387–394.Google Scholar
- Rinzler AG, Liu J, Dai H, Nikolaev P, Huffman CB, Rodriguez-Macias FJ, Boul PJ, Lu AH, Heymann D, Colbert DT: Large-scale purification of single-wall carbon nanotubes: process, product, and characterization. Appl Phys A Mater Sci Process 1998, 67(1):29–37.Google Scholar
- Gu Z, Peng H, Hauge RH, Smalley RE, Margrave JL: Cutting single-wall carbon nanotubes through fluorination. Nano Lett 2002, 2(9):1009–1013.Google Scholar
- Popov VN: Carbon nanotubes: properties and application. Materials Science and Engineering: R: Reports 2004, 43(3):61–102.Google Scholar
- Baughman RH, Zakhidov AA, de Heer WA: Carbon nanotubes—the route toward applications. Science 2002, 297(5582):787–792.Google Scholar
- Terrones M: Science and technology of the twenty-first century: synthesis, properties, and applications of carbon nanotubes. Annu Rev Mater Res 2003, 33(1):419–501.Google Scholar
- Dai H, Wong EW, Lu YZ, Fan S, Lieber CM: Synthesis and characterization of carbide nanorods. Nature 1995, 375(6534):769–772.Google Scholar
- Ajayan PM, Zhou OZ: Applications of carbon nanotubes. In Carbon nanotubes. China: Springer; 2001:391–425.Google Scholar
- de Heer WA: Nanotubes and the pursuit of applications. MRS Bull 2004, 29(04):281–285.Google Scholar
- Han W, Fan S, Li Q, Hu Y: Synthesis of gallium nitride nanorods through a carbon nanotube-confined reaction. Science 1997, 277(5330):1287–1289.Google Scholar
- Ye X, Lin Y, Wang C, Wai CM: Supercritical fluid fabrication of metal nanowires and nanorods templated by multiwalled carbon nanotubes. Adv Mater 2003, 15(4):316–319.Google Scholar
- Bower C, Rosen R, Jin L, Han J, Zhou O: Deformation of carbon nanotubes in nanotube—polymer composites. Appl Phys Lett 1999, 74(22):3317–3319.Google Scholar
- Wu HQ, Wei XW, Shao MW, Gu JS: Synthesis of zinc oxide nanorods using carbon nanotubes as templates. J Cryst Growth 2004, 265(1):184–189.Google Scholar
- Calvert P: Nanotube composites: a recipe for strength. Nature 1999, 399(6733):210–211.Google Scholar
- Marquis FD: Fully integrated hybrid polymeric carbon nanotube composites. Trans Tech Publ 2003, 100: 85–88.Google Scholar
- Bian Z, Wang RJ, Wang WH, Zhang T, Inoue A: Carbon-nanotube-reinforced Zr-based bulk metallic glass composites and their properties. Adv Funct Mater 2004, 14(1):55–63.Google Scholar
- Flahaut E, Rul S, Laurent C, Peigney A: Carbon Nanotubes-Ceramic Composites. Ceramic Nanomaterials and Nanotechnology II 2004, 148: 69–82.Google Scholar
- Yanagi H, Kawai Y, Kita T, Fujii S, Hayashi Y, Magario A, Noguchi T: Carbon nanotube/aluminum composites as a novel field electron emitter. Jpn J Appl Phys 2006, 45(7L):L650.Google Scholar
- Baughman RH, Cui C, Zakhidov AA, Iqbal Z, Barisci JN, Spinks GM, Wallace GG, Mazzoldi A, De Rossi D, Rinzler AG: Carbon nanotube actuators. Science 1999, 284(5418):1340–1344.Google Scholar
- Niu C, Sichel EK, Hoch R, Moy D, Tennent H: High power electrochemical capacitors based on carbon nanotube electrodes. Appl Phys Lett 1997, 70(11):1480–1482.Google Scholar
- Dai H, Hafner JH, Rinzler AG, Colbert DT, Smalley RE: Nanotubes as nanoprobes in scanning probe microscopy. Nature 1996, 384(6605):147–150.Google Scholar
- Tibbetts GG, Meisner GP, Olk CH: Hydrogen storage capacity of carbon nanotubes, filaments, and vapor-grown fibers. Carbon 2001, 39(15):2291–2301.Google Scholar
- Wei J, Zhu H, Wu D, Wei B: Carbon nanotube filaments in household light bulbs. Appl Phys Lett 2004, 84(24):4869–4871.Google Scholar
- Wang Y, Da S, Kim MJ, Kelly KF, Guo W, Kittrell C, Hauge RH, Smalley RE: Ultrathin “bed-of-nails” membranes of single-wall carbon nanotubes. J Am Chem Soc 2004, 126(31):9502–9503.Google Scholar
- Chen S, Yuan R, Chai Y, Min L, Li W, Xu Y: Electrochemical sensing platform based on tris (2, 2′-bipyridyl) cobalt (III) and multiwall carbon nanotubes-Nafion composite for immunoassay of carcinoma antigen-125. Electrochim Acta 2009, 54(28):7242–7247.Google Scholar
- Lacerda L, Bianco A, Prato M, Kostarelos K: Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Deliv Rev 2006, 58(14):1460–1470.Google Scholar
- Zhang L, Webster TJ: Nanotechnology and nanomaterials: promises for improved tissue regeneration. Nano Today 2009, 4(1):66–80.Google Scholar
- Kam NWS, O'Connell M, Wisdom JA, Dai H: Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci U S A 2005, 102(33):11600–11605.Google Scholar
- Ding RG, Lu GQ, Yan ZF, Wilson MA: Recent advances in the preparation and utilization of carbon nanotubes for hydrogen storage. J Nanosci Nanotechnol 2001, 1(1):7–29.Google Scholar
- Aoki N, Yokoyama A, Nodasaka Y, Akasaka T, Uo M, Sato Y, Tohji K, Watari F: Cell culture on a carbon nanotube scaffold. J Biomed Nanotechnol 2005, 1(4):402–405.Google Scholar
- Abarrategi A, Gutierrez MC, Moreno-Vicente C, Ramos V, Lopez-Lacomba JL, Ferrer ML, del Monte F: Multiwall carbon nanotube scaffolds for tissue engineering purposes. Biomaterials 2008, 29(1):94–102.Google Scholar
- Hirata E, Uo M, Takita H, Akasaka T, Watari F, Yokoyama A: Development of a 3D collagen scaffold coated with multiwalled carbon nanotubes. J Biomed Mater Res B Appl Biomater 2009, 90(2):629–634.Google Scholar
- Meng J, Kong H, Han Z, Wang C, Zhu G, Xie S, Xu H: Enhancement of nanofibrous scaffold of multiwalled carbon nanotubes/polyurethane composite to the fibroblasts growth and biosynthesis. J Biomed Mater Res A 2009, 88(1):105–116.Google Scholar
- Yildirim ED, Yin X, Nair K, Sun W: Fabrication, characterization, and biocompatibility of single-walled carbon nanotube-reinforced alginate composite scaffolds manufactured using freeform fabrication technique. J Biomed Mater Res B Appl Biomater 2008, 87(2):406–414.Google Scholar
- Chao TI, Xiang S, Chen CS, Chin WC, Nelson AJ, Wang C, Lu J: Carbon nanotubes promote neuron differentiation from human embryonic stem cells. Biochem Biophys Res Commun 2009, 384(4):426–430.Google Scholar
- Shi X, Sitharaman B, Pham QP, Spicer PP, Hudson JL, Wilson LJ, Tour JM, Raphael RM, Mikos AG: In vitro cytotoxicity of single-walled carbon nanotube/biodegradable polymer nanocomposites. J Biomed Mater Res A 2008, 86(3):813–823.Google Scholar
- Harrison BS, Atala A: Carbon nanotube applications for tissue engineering. Biomaterials 2007, 28(2):344–353.Google Scholar
- Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K: Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A 2006, 103(9):3357–3362.Google Scholar
- Wang SF, Shen L, Zhang WD, Tong YJ: Preparation and mechanical properties of chitosan/carbon nanotubes composites. Biomacromolecules 2005, 6(6):3067–3072.Google Scholar
- MacDonald RA, Laurenzi BF, Viswanathan G, Ajayan PM, Stegemann JP: Collagen-carbon nanotube composite materials as scaffolds in tissue engineering. J Biomed Mater Res A 2005, 74(3):489–496.Google Scholar
- Castillo JJ, Svendsen WE, Rozlosnik N, Escobar P: Detection of cancer cells using a peptide nanotube-folic acid modified graphene electrode. Analyst 2013, 138(4):1026–1031.Google Scholar
- Eatemadi A, Daraee H, Zarghami N, Hassan Melat Y, Abolfazl A: Nanofiber: synthesis and biomedical applications, artificial cells, nanomedicine, and biotechnology. 2014, 43(7):1–11.Google Scholar
- Hong H, Gao T, Cai W: Molecular imaging with single-walled carbon nanotubes. Nano Today 2009, 4(3):252–261.Google Scholar
- Li C, Curreli M, Lin H, Lei B, Ishikawa FN, Datar R, Cote RJ, Thompson ME, Zhou C: Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes. J Am Chem Soc 2005, 127(36):12484–12485.Google Scholar
- Yu X, Munge B, Patel V, Jensen G, Bhirde A, Gong JD, Kim SN, Gillespie J, Gutkind JS, Papadimitrakopoulos F: Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J Am Chem Soc 2006, 128(34):11199–11205.Google Scholar
- Okuno J, Maehashi K, Kerman K, Takamura Y, Matsumoto K, Tamiya E: Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes. Biosens Bioelectron 2007, 22(9):2377–2381.Google Scholar
- Ou C, Yuan R, Chai Y, Tang M, Chai R, He X: A novel amperometric immunosensor based on layer-by-layer assembly of gold nanoparticles-multi-walled carbon nanotubes-thionine multilayer films on polyelectrolyte surface. Anal Chim Acta 2007, 603(2):205–213.Google Scholar
- Wu L, Yan F, Ju H: An amperometric immunosensor for separation-free immunoassay of CA125 based on its covalent immobilization coupled with thionine on carbon nanofiber. J Immunol Methods 2007, 322(1):12–19.Google Scholar
- Ding Y, Liu J, Jin X, Lu H, Shen G, Yu R: Poly-L-lysine/hydroxyapatite/carbon nanotube hybrid nanocomposite applied for piezoelectric immunoassay of carbohydrate antigen 19–9. Analyst 2008, 133(2):184–190.Google Scholar
- Sánchez S, Roldán M, Pérez S, Fàbregas E: Toward a fast, easy, and versatile immobilization of biomolecules into carbon nanotube/polysulfone-based biosensors for the detection of hCG hormone. Anal Chem 2008, 80(17):6508–6514.Google Scholar
- Li N, Yuan R, Chai Y, Chen S, An H: Sensitive immunoassay of human chorionic gonadotrophin based on multi-walled carbon nanotube-chitosan matrix. Bioprocess Biosyst Eng 2008, 31(6):551–558.Google Scholar
- Panini NV, Messina GA, Salinas E, Raba J: Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA) in human serum samples. Biosens Bioelectron 2008, 23(7):1145–1151.Google Scholar
- Lin YY, Wang J, Liu G, Wu H, Wai CM, Lin Y: A nanoparticle label/immunochromatographic electrochemical biosensor for rapid and sensitive detection of prostate-specific antigen. Biosens Bioelectron 2008, 23(11):1659–1665.Google Scholar
- Kim JP, Lee BY, Lee J, Hong S, Sim SJ: Enhancement of sensitivity and specificity by surface modification of carbon nanotubes in diagnosis of prostate cancer based on carbon nanotube field effect transistors. Biosens Bioelectron 2009, 24(11):3372–3378.Google Scholar
- Ho JAA, Lin YC, Wang LS, Hwang KC, Chou PT: Carbon nanoparticle-enhanced immunoelectrochemical detection for protein tumor marker with cadmium sulfide biotracers. Anal Chem 2009, 81(4):1340–1346.Google Scholar
- Lin J, He C, Zhang L, Zhang S: Sensitive amperometric immunosensor for α-fetoprotein based on carbon nanotube/gold nanoparticle doped chitosan film. Anal Biochem 2009, 384(1):130–135.Google Scholar
- Bi S, Zhou H, Zhang S: Multilayers enzyme-coated carbon nanotubes as biolabel for ultrasensitive chemiluminescence immunoassay of cancer biomarker. Biosens Bioelectron 2009, 24(10):2961–2966.Google Scholar
- Heister E, Neves V, Lipert K, Coley HM, Silva SR, McFadden J: Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy. Carbon 2009, 47(9):2152–2160.Google Scholar
- Jabr-Milane LS, van Vlerken LE, Yadav S, Amiji MM: Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat Rev 2008, 34(7):592–602.Google Scholar
- Goldstein D, Nassar T, Lambert G, Kadouche J, Benita S: The design and evaluation of a novel targeted drug delivery system using cationic emulsion-antibody conjugates. J Control Release 2005, 108(2):418–432.Google Scholar
- Zhang X, Meng L, Lu Q, Fei Z, Dyson PJ: Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 2009, 30(30):6041–6047.Google Scholar
- Chen J, Chen S, Zhao X, Kuznetsova LV, Wong SS, Ojima I: Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc 2008, 130(49):16778–16785.Google Scholar
- Bhirde AA, Patel V, Gavard J, Zhang G, Sousa AA, Masedunskas A, Leapman RD, Weigert R, Gutkind JS, Rusling JF: Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 2009, 3(2):307–316.Google Scholar
- Dhar S, Liu Z, Thomale J, Dai H, Lippard SJ: Targeted single-wall carbon nanotube-mediated Pt (IV) prodrug delivery using folate as a homing device. J Am Chem Soc 2008, 130(34):11467–11476.Google Scholar
- Liu Z, Sun X, Nakayama-Ratchford N, Dai H: Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 2007, 1(1):50–56.Google Scholar
- McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA: Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med 2007, 48(7):1180–1189.Google Scholar
- Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H: Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 2008, 68(16):6652–6660.Google Scholar
- Zhang Z, Yang X, Zhang Y, Zeng B, Wang S, Zhu T, Roden RB, Chen Y, Yang R: Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth. Clin Cancer Res 2006, 12(16):4933–4939.Google Scholar
- Podesta JE, Al-Jamal KT, Herrero MA, Tian B, Ali-Boucetta H, Hegde V, Bianco A, Prato M, Kostarelos K: Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model. Small 2009, 5(10):1176–1185.Google Scholar
- Qiao J, Hong T, Guo H, Xu YQ, Chung DH: Single-walled carbon nanotube-mediated small interfering RNA delivery for gastrin-releasing peptide receptor silencing in human neuroblastoma. In NanoBiotechnology Protocols. Springer: Springer; 2013:137–147.Google Scholar
- Yang R, Yang X, Zhang Z, Zhang Y, Wang S, Cai Z, Jia Y, Ma Y, Zheng C, Lu Y: Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells. Gene Ther 2006, 13(24):1714–1723.Google Scholar
- Akbarzadeh A, Zarghami N, Mikaeili H, Asgari D, Goganian AM, Khiabani K, Samiei M, Davaran S: Synthesis, characterization and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin. Nano Technol Sci Appl 2012, 5: 1–13.Google Scholar
- Akbarzadeh A, Mikaeili H, Zarghami N, Mohammad R, Bsrkhordari A, Davaran S: Preparation and in-vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymer. Int J Nanomed 2012, 7(38):511–516.Google Scholar
- Akbarzadeh A, Samiei M, Davaran S: Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Lett 2012, 7: 144.Google Scholar
- Valizadeh A, Mikaeili H, Samiei M, Farkhani SM, Zarghami N, Kouhi M, Akbarzadeh A, Davaran S: Quantum dots: synthesis, bioapplications, and toxicity Nanoscale. Res Lett 2012, 7: 480.Google Scholar
- Akbarzadeh A, Samiei M, Joo SW, Anzaby M, Hanifehpour Y, Nasrabadi HT, Davaran S: Synthesis, characterization and in vitro studies of doxorubicin loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line. J Nano biotechnol 2012, 110: 46.Google Scholar
- Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K: Liposome: classification, preparation, and applications. Nanoscale Res Lett 2013, 8: 102.Google Scholar
- Pourhassan-Moghaddam M, Rahmati-Yamchi M, Ak- Barzadeh A, Daraee H, Nejati-Koshki K, Hanifehpour Y, Joo SW: Protein detection through different platforms of immuno-loop-mediated isothermal amplification. Nanoscale Res Lett 2013, 8: 485.Google Scholar
- Mollazade M, Nejati-Koshki K, Akbarzadeh A, Ha- Nifehpour Y, Zarghami N, Joo SW: PAMAM dendrimers augment inhibitory effect of curcumin on cancer cell proliferation: possible inhibition of telomerase. 2013.Google Scholar
- Ghasemali S, Akbarzadeh A, Alimirzalu S, Rahmati Yamchi M, Barkhordari A, Tozihi M, Kordi SH: Study of inhibitory effect of b-Cyclo- dextrin-helenalin complex on HTERT gene expression in T47D breast cancer cell line by real time quantitative PCR(q-PCR). 2013.Google Scholar
- Nejati-Koshki K, Akbarzadeh A, Pourhasan-Moghadam M, Joo SW: Inhibition of leptin and leptin receptor gene expression by silibinin-curcumin combination. 2013.Google Scholar
- Rezaei-Sadabady R, Zarghami N, Barzegar A, Eidi A, Akbarzadeh A, Rezaei-Tavirani M: Studies of the relationship between structure and antioxidant activity in interesting systems, including tyrosol, hydroxytyrosol derivatives indicated by quantum chemical calculations. Soft 2013, 2: 13–18.Google Scholar
- Ebrahimnezhad Z, Zarghami N, Keyhani M, Amirsaadat S, Akbarzadeh A, Rahmati M, Taheri ZM, Nejati-Koshki K: Inhibition of hTERT gene expression by silibinin-loaded PLGA-PEG-Fe3O4 in T47D breast cancer cell line. Bioimpacts 2013, 3: 67–74.Google Scholar
- Abbasi E, Milani M, Sedigheh Fekri A, Mohammad K, Abolfazl A, Hamid Tayefi N, Parisa N, San Woo J, Younes H, Kazem N-K, Mohammad S: Silver nanoparticles: synthesis methods, bio-applications and properties. Critical Reviews in Microbiology 2014, 46(6):1–8.Google Scholar
- Mirakabad FST, Akbarzadeh A, Zarghami N, Zeighamian V, Rahimzadeh A, Alimohammadi S: PLGA-cased nanoparticles as cancer drug delivery systems. APJCP Asian Pac J Cancer Prev 2014, 15(1):517–535.Google Scholar
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