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Table 6 Example of drugs and nucleic acids which were delivered by carbon nanotubes

From: Carbon nanotubes: properties, synthesis, purification, and medical applications

Drug/nucleic acid CNT type Cell or tissue Properties Reference
Taxoid SWNTs Leukemia High potency toward specific cancer cell lines [116]
Doxorubicin SWNTs Colon cancer Efficiently taken up by cancer cells, then translocates to the nucleus while the nanotubes remain in the cytoplasm [113, 114]
Cisplatin SWNTs Squamous carcinoma Rapid regression of tumor growth [117]
Cisplatin SWNTs Nasopharyngeal epidermoid carcinoma, etc. High and specific binding to the folate receptor (FR) for the SWNT-1 conjugate [118]
Doxorubicin SWNTs Breast cancer Glioblastoma Show that large surface areas on single-walled carbon nanotubes (SWNTs) [119]
Doxorubicin SWNTs Cervical carcinoma Increase nuclear DNA damage and inhibit the cell proliferation [115]
Radionuclide SWNTs Burkitt lymphoma The selective targeting of tumor in vitro and in vivo [120]
Paclitaxel SWNTs Breast cancer High treatment efficacy, minimum side effects [121]
siRNA SWNTs Tumor cells both in vitro and in vivo mouse models Increase suppression of tumor growth [122]
Toxic siRNA sequence (siTOX) Functionalized MWNTs Human lung xenograft model Significant tumor growth inhibition [123]
siRNA SWNT Human neuroblastoma Enhance the efficiency of siRNA-mediated gastrin-releasing peptide receptor (GRP-R) gene silencing [124]
SOCS1 siRNA sWNT Dendritic cells (DCs) Reduced SOCS1 expression and retarded the growth of established B16 tumor in mice [125]