|
Parameter
|
Unit
|
Free ADR
|
Non-irrad
|
Irrad
|
|---|
|
t1/2α
|
h
|
0.20 ± 0.02
|
0.19 ± 0.04
|
0.21 ± 0.05
|
|
t1/2β
|
h
|
0.98 ± 0.19
|
3.89 ± 0.79
|
1.57 ± 1.31
|
|
t1/2γ
|
h
|
9.56 ± 4.06
|
21.13 ± 1.50
|
34.53 ± 2.63
|
|
CL
|
mL/h
|
30.96 ± 5.86
|
8.82 ± 4.54
|
6.63 ± 3.74
|
|
C
max
|
μg/mL
|
50.45 ± 5.54
|
54.13 ± 4.34
|
53.04 ± 5.68
|
|
AUC0-t
|
(μg/mL) · h
|
79.97 ± 11.36
|
447.19 ± 54.19
|
713.49 ± 120.51
|
|
MRT
|
h
|
6.37 ± 2.15
|
27.54 ± 1.53
|
48.58 ± 4.67
|
- t1/2, the elimination half time; CL, clearance; Cmax, the maximum observed concentration in the plasma; AUC, area under the concentration-time curve; MRT, mean residence time.
