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Table 2 Tumor bearing nude mice serum pharmacokinetic parameters comparing free and liposomal ADRs ( n= 3)

From: Potentiating antilymphoma efficacy of chemotherapy using a liposome for integration of CD20 targeting, ultra-violet irradiation polymerizing, and controlled drug delivery

Parameter Unit Free ADR Non-irrad Irrad
t1/2α h 0.20 ± 0.02 0.19 ± 0.04 0.21 ± 0.05
t1/2β h 0.98 ± 0.19 3.89 ± 0.79 1.57 ± 1.31
t1/2γ h 9.56 ± 4.06 21.13 ± 1.50 34.53 ± 2.63
CL mL/h 30.96 ± 5.86 8.82 ± 4.54 6.63 ± 3.74
C max μg/mL 50.45 ± 5.54 54.13 ± 4.34 53.04 ± 5.68
AUC0-t (μg/mL) · h 79.97 ± 11.36 447.19 ± 54.19 713.49 ± 120.51
MRT h 6.37 ± 2.15 27.54 ± 1.53 48.58 ± 4.67
  1. t1/2, the elimination half time; CL, clearance; Cmax, the maximum observed concentration in the plasma; AUC, area under the concentration-time curve; MRT, mean residence time.