Skip to main content

Table 1 Characteristics of some CTC detection methods

From: Nanotechnology for the detection and kill of circulating tumor cells

Method Cell viability Detection level Advantage Disadvantage Reference
CellSearch System No Median number of isolated CTCs, 5 CTCs per 7.5 ml of blood Adequate clinical evidence, automated enumeration, commercial availability Further analysis limited, false-positive and false-negative, applications need to be expanded [18, 25, 26]
CellSearch Profile No Median number of isolated CTCs, about 140 CTCs per 7.5 ml of blood Fewer processing steps, better sensitivity, reproducibility Manual enumeration, false-positive and false-negative, limited reports [32]
AdnaSystem No Sensitivity, 2 CTCs per 5 ml of blood Detection of occult or very low number of CTCs, assessment of genomic markers False-positive and false-negative, the sensitivity not improved compared to CellSearch System [19, 37]
Immunomagnetic nanocarrier platform Yes Capture rate, 78% to 93% High capture rate, fewer processing steps, altered biomarkers Lacks clinical study, limited reports [20]
Hybrid nanoparticle Yes Capture rate, 87.5% High capture rate, fewer processing steps Lacks clinical study, limited reports [41]
One-step method No Capture rate, about 3/1,000 Convenient process, low cost Low capture rate, lacks clinical data, false-negative [21]
μ-Nuclear magnetic resonance No Capture rate, 99.2% High sensitivity, short measurement time Lacks clinical study [42, 43]
Aptamer-conjugated gold nanoparticles No The limit of detection is 90 cells Bare eyes sense the color change, the detection is rapid Unable enumeration, CTC detection is still few [22, 47]
CTC microseparator Yes Isolates about 90% of CTCs The step is simple and high throughput, the further can be carried out Lacks clinical study [23, 49, 50]