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Figure 3 | Nanoscale Research Letters

Figure 3

From: Potential applications of magnetic particles to detect and treat Alzheimer's disease

Figure 3

Images of amyloid plaques. Amyloid plaques detected with in vivo μMRI after intravenous femoral injection of SPIONs-Aβ(1–42) with mannitol. In vivo T2*-weighted MRI images show a 14-month-old wild-type (A) and transgenic (B) mouse brain. Note the match of many large plaques (arrowheads) in immunohistochemistry (D) and μMRI (B) in the AD transgenic mice. (C) Lack of plaque detection in a wild-type mouse following SPION-Aβ(1–42) injection (from [30], with permission).

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