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Figure 4 | Nanoscale Research Letters

Figure 4

From: Potential applications of magnetic particles to detect and treat Alzheimer's disease

Figure 4

The bio-barcode amplification assay. The assay uses magnetic particles functionalized with monoclonal antibodies that recognize and bind ADDLs. The ADDLs are then sandwiched with a nanoparticle probe, modified with double-stranded DNA and an anti-ADDL polyclonal antibody. After repeated washing while using a magnet to immobilize the magnetic particles, a dehybridization step releases hundreds of barcode DNA strands for each antigen-binding event (From [39]. Copyright (2005) National Academy of Sciences, USA).

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