Figure 5

In vitro growth inhibitory effects of S-DM1 and FA-DM1-NPs on MCF-7/HER2 cells. The anticancer effects of FA-DM1-NPs and S-DM1 were tested at concentrations of 0.001, 0.01, 0.1, and 1.0 and 10.0 μg/mL after treatment for 48 and 72 h, respectively. Both drug inhibited the growth of MCF-7/HER2 cells in a dose-dependent manner, but the effect on FA-DM1-NPs had no difference with that of S-DM1 in the concentration range of 0.01 to 10.0 μg/mL (p >0.05).