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Figure 8 | Nanoscale Research Letters

Figure 8

From: Enhanced anticancer activity of DM1-loaded star-shaped folate-core PLA-TPGS nanoparticles

Figure 8

Residual cancer cells in FA-DM1-NPs treated MCF-7/HER2 xenografts. Residual cancer cell aggregates were found from the tumor samples in two of ten xenografted mice after FA-DM1-NP treatment. The level of oncogene Her2 (FISH), tumor cell division phase index Ki-67 (IHC) positive ratio, and the expression level of HER2 (IHC) in the MCF-7/HER2 cells of the FA-DM1-NP post-treatment were lower compared with those of pre-treatment (×100). Yellow scale bar 10 μm and black scale bar 50 μm. The few surviving in the tumor tissue FA-DM1-NP treatment group after treatment, the level of oncogene Her2, tumor cell division phase index Ki-67, and the HER2 expression level of tumor cells were significantly reduced, even disappeared, which suggested that the existence of the typical MCF-7/HER2 tumor cells had significantly declined. This may be due to FA-DM1-NPs combining folate receptor (FR) of the tumor cells effectively to induce the FA-DM1-NPs internalize and release the entrapped drug DM1, and then play the biological effects of antitumor. These data suggested that FA-DM1-NPs can be more effectively enriched in FR+ MCF-7/HER2 tumor cells and have more effective antitumor as compare to S-DM1.

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