Skip to main content
SpringerLink
Account
Figure 4 | Nanoscale Research Letters

Figure 4

From: Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

Figure 4

Time-dependent changes in the specific activity of CYPs exposed to AuNPs for different preincubation periods. The preincubation was performed in a PBS buffer (100 mM, pH 7.4) at 37°C, containing 2 mg/mL HLM, 100 μM 5-nm AuNPs with or without 1 mM NADPH, followed by a tenfold dilution of the preincubation reaction mixture into the second incubation for measuring the residual CYP activity toward individual probe substrates. The CYP preincubations for 0 min were used as the control incubations (100%), and error bars indicate the SD values.

Back to article page

Search

Navigation