Table 3 Top affected gene-gene interaction networks after sub-chronic SWCNT exposure in transformed BEAS-2B cells
Top diseases and functions | Molecules in network a,b | Score | Focus molecules c |
---|---|---|---|
Cellular growth and proliferation, hematological system development and function, humoral immune response | ADAM15, ADRBK2, ATP5B, BCL10, BCR (complex), CHGA, CR2, CRHR1, ERK1/2, FGR, GNAZ, HOPX, HSD11B2, HSPD1, HTATIP2, IgG1, Igg3, IgG2b, IGLL1/IGLL5, Igm, insulin, ITCH, Jnk, MFGE8, NEU1, PAK2, PAX4, PPP1R1B, Ras, RASGRP1, SH2B2, SH2D2A, TAS1R1, Vegf, ZNF24 | 35 | 25 |
Connective tissue disorders, inflammatory disease, skeletal and muscular disorders | C1R, CD33, CD59, CDON, G6PD, HLA-A, HLA-B, HLA-C, HLA-E, Ifnar, IgG, IKK (complex), immunoglobulin, interferon alpha, KIR, KRT31, MYO1E, NFAT5, NFkB (complex), P38 MAPK, PI3K (family), PIM1, Pkc(s), RHOB, RNF34, RTKN, SCARB1, SIRPA, SLC6A6, Tap, TAPBP, TNFSF10, TRAF3IP2, USP11, USP18 | 33 | 24 |
Cell death and survival, embryonic development, organismal development | ADAM17, AFF4, AKT2, Akt, AMPK, Ap1, BHLHE40, CD68, CELF1, CSNK1E, CSNK1G2, Cyclin A, DVL1, estrogen receptor, F actin, FMR1, GSK3B, HMGB3, HMGN5, Hsp70, IGFBP2, LCP1, LDL, MGLL, MUC4, OSGIN1, PDGF BB, PI3K (complex), PMAIP1, Ppp2c, PURA, SF3B3, STRN, USP6, USP33 | 33 | 24 |
Cellular compromise, skeletal and muscular system development and function, post-translational modification | ARHGEF9, ATP13A2, CD3, Cg, Creb, CTSB, DUSP9, ERK, FBN1, FGF3, FSHR, GSTM4, Hdac, Histone h3, Histone h4, HSD17B1, IFI44, IFI44L, IgG2a, KDM3A, Lh, MCOLN1, MT1F, MT1X, NDRG1, NDRG4, NES, NPNT, ORAI1, OXT, PGK1, SOX12, STAT5a/b, STK17A, TCR | 33 | 24 |
Cell morphology, cellular assembly and organization, cellular development | ACBD7, ADAM22, ANK1, AR, AS3MT, ATP5S, ATP6V0E2, ATP8B1, CACNA1E, CDC6, CHD8, DLG4, FARP1, GLUL, GPR182, GSTM1, HILPDA, HIST1H1A, IGF1R, KCNA4, KCNAB2, MCM8, NIPSNAP1, NUPR1, PPT2, RAB18, RCN2, SIPA1L1, SOX11, ST6GALNAC6, SYNGAP1, TEX2, TMEM30A, WNK1, ZSCAN16 | 21 | 18 |
Respiratory system development and function, tissue morphology, cell cycle | 26 s Proteasome, ACTC1, ACTN1, ACTR2, ACTR3, BNIP3L, CAP2, CARD10, CKAP2, EBAG9, ELMOD3, ENC1, FAM89B, FSH, GEM, IGLL1/IGLL5, ING2, JMJD6, MED26, MT1L, NOL3, NR3C1, PRPH, PSMB1, RAB11A, RDM1, RNA polymerase II, SCAF8, SERTAD2, SFTPC, SIAH2, SMARCC1, TFDP2, TUBA4A, USP13 | 16 | 15 |
Cancer, gastrointestinal disease, hepatic system disease | ACOT11, AHCY, ANXA7, ARL6IP1, ARNT, ASS1, AXIN1, AXIN2, BCLAF1, CAMLG, CCDC80, CYP1A1, EPHX1, FAM120A, FBXW7, HIST1H1C, IGFBP2, KAT5, KITLG, KREMEN2, MED13L, MT1H, N-cor, NCOR2, NQO1, PIAS2, PSMF1, PTGDS, PTP4A3, RBBP4, SERPINB6, SIDT2, STOX1, TCF7L2, TP53 | 16 | 15 |
Cell morphology, cell-to-cell signaling and interaction, nervous system development and function | AIG1, ALDH3B1, C11orf30, CABYR, CACNA2D1, CHMP4B, COX10, CYFIP2, DGKZ, DMD, DNAJB6, DTNB, DYRK1A, HDAC4, HYOU1, INS, LEPR, Map4k4, MARK3, OPN4, Pdx1, PFKM, PPFIA1, proinsulin, SNCA, SNTB2, SPARC, SPOP, TNRC6B, TRIM44, TUBB4A, VEGFA, VGF, YWHAG, YWHAH | 16 | 15 |
DNA replication, recombination, and repair, cellular compromise, cell death and survival | ATP6V0E1, BAG1, BAX, BGN, BRCA1, BRCA2, CCND1, CEL, CKB, DDX5, DNAJA1, DPYSL3, FANCD2, GATA1, GFI1B, GSK3A, H3F3A/H3F3B, Hbb-b2, HSPA4, HSPD1, LATS1, LINC00467, MAPT, NGFR, NME4, OPA1, ROCK2, SFN, SPOCK2, STIP1, TLE1, UBE2N, USP11, ZFPM1, ZNF324 | 15 | 14 |
Lipid metabolism, molecular transport, small molecule biochemistry | AP1M2, APOA1, APOC1, ARCN1, CBS, CCL1, CCL22, CETP, CLIC4, COG3, COPG1, COPZ1, CXCL5, ERN1, EYA4, GSTA1, HLA-J, HYOU1, IFNB1, LCAT, MGLL, NPEPPS, Pdx1, PEX6, PHLDB2, PPARG, PTGES2, RGS14, RNASE1, TBXAS1, TMEM173, TNF, TPM2, Trim30a/Trim30d, XBP1 | 15 | 14 |