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Table 2 Microanatomical characteristic of tissue collected from different organs

From: Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity

Organ

Microanatomical characteristic of tissue

Percentage of characteristic founded (%)

p value; Chi-square

Group

0.25 mg/ml

1 mg/ml

Control

Liver

Macrovesicularsteatosis

33.3 (3/9)

0 (0/7)

37.5 (3/8)

0.189

Sinusoidal congestion

100 (9/9)

100 (7/7)

100 (8/8)

-

Pyknotic nuclei

88.9 (8/9)

0 (0/7)*

62.5 (5/8)

0.002

Glycogen storage

77.8 (7/9)

71.4 (5/7)

75 (6/8)

0.959

Lymphocyte aggregation

11.1 (1/9)

57.1 (4/7)*

0 (0/8)

0.016

Spleen

Normal

100 (9/9)

100 (7/7)

100 (8/8)

-

Kidney

Normal

100 (9/9)

100 (7/7)

100 (8/8)

-

Testis

Normal

100 (9/9)

100 (7/7)

100 (8/8)

-

Brain

Normal

100 (9/9)

100 (7/7)

100 (8/8)

-

  1. The liver, spleen, kidney, testis, and brain of rats fed with cordycepin every day for consecutive 30 days; *indicates significant difference compared to control (p < 0.05).

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