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Table 2 Microanatomical characteristic of tissue collected from different organs

From: Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity

Organ Microanatomical characteristic of tissue Percentage of characteristic founded (%) p value; Chi-square
Group
0.25 mg/ml 1 mg/ml Control
Liver Macrovesicularsteatosis 33.3 (3/9) 0 (0/7) 37.5 (3/8) 0.189
Sinusoidal congestion 100 (9/9) 100 (7/7) 100 (8/8) -
Pyknotic nuclei 88.9 (8/9) 0 (0/7)* 62.5 (5/8) 0.002
Glycogen storage 77.8 (7/9) 71.4 (5/7) 75 (6/8) 0.959
Lymphocyte aggregation 11.1 (1/9) 57.1 (4/7)* 0 (0/8) 0.016
Spleen Normal 100 (9/9) 100 (7/7) 100 (8/8) -
Kidney Normal 100 (9/9) 100 (7/7) 100 (8/8) -
Testis Normal 100 (9/9) 100 (7/7) 100 (8/8) -
Brain Normal 100 (9/9) 100 (7/7) 100 (8/8) -
  1. The liver, spleen, kidney, testis, and brain of rats fed with cordycepin every day for consecutive 30 days; *indicates significant difference compared to control (p < 0.05).