Skip to main content
Fig. 1 | Nanoscale Research Letters

Fig. 1

From: Enhanced Antifungal Activity by Ab-Modified Amphotericin B-Loaded Nanoparticles Using a pH-Responsive Block Copolymer

Fig. 1

Synthesis procedure for forming the PLGA-PLH-PEG copolymer. End-grafting strategy was employed to form the desired PLGA-PLH-PEG copolymer. The C-terminal Cys of the PLH block reacts with the orthopyridyldisulfide-modified end group of PEG to form the PLH-PEG copolymer and then activates the PLGA-COOH using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). Lastly, PEG-PLH and PLGA-NHS polymers are conjugated using the N-terminal Lys to form the desired PLGA-PLH-PEG copolymer

Back to article page