Fig. 4

Photomicrograph of sections in rat liver intoxicated with CNPs (H and E ×400). a Group I showing normal hepatic parenchyma. Group II showing b focal area of hepatocellular necrosis infiltrated by mononuclear cells, c polyploidy hepatocytes represented by hepatic cytokaryomegaly, binucleated hepatocytes associated with activation of Kupffer cells and sporadic cell necrosis d apoptosis, e oval cell proliferation,hyperplasia of biliary epithelium and formation of newly formed bile ductule and f periportal sporadic hepaticcell necrosis. g Group III showing individual cell necrosis. h Group IV showing normal hepatic parenchyma