Biodistribution of a High Dose of Diamond, Graphite, and Graphene Oxide Nanoparticles After Multiple Intraperitoneal Injections in Rats

Kurantowicz, Natalia; Strojny, Barbara; Sawosz, Ewa; Jaworski, Sławomir; Kutwin, Marta; Grodzik, Marta; Wierzbicki, Mateusz; Lipińska, Ludwika; Mitura, Katarzyna; Chwalibog, André

doi:10.1186/s11671-015-1107-9

Table 5 Summary of carbon nanoparticles in vivo accumulation with emphasis on exposure routes

From: Biodistribution of a High Dose of Diamond, Graphite, and Graphene Oxide Nanoparticles After Multiple Intraperitoneal Injections in Rats

Nanoparticles	Original nanoparticle name	Exposure route	Investigated animal	Nanoparticles present in organs	Reference
Graphene	PEGylated nanographene sheets wih Cy7	Intravenous	BALB/c mice	Kidney and excreted in urine	[16]
Graphene oxide	¹²⁵I-nGO-PEG	Intraperitoneal	BALB/c mice	Liver, spleen	[17]
	¹²⁵I-RGO-PEG
	¹²⁵I-nRGO-PEG
Graphene oxide	¹²⁵I-nGO-PEG	Intragastrically	BALB/c mice	Stomach, intestine	[17]
	¹²⁵I-RGO-PEG
	¹²⁵I-nRGO-PEG
Graphene oxide	¹²⁵I-nGO-PEG	Intravenous	BALB/c mice	Liver, spleen	[18]
	¹²⁵I-RGO-PEG
	¹²⁵I-nRGO-PEG
Graphene oxide	Graphene oxide	Intravenous	BALB/c mice	Lungs, liver	[33]
Graphene oxide	Graphene oxide + Tween 80	Intravenous	BALB/c mice	Liver	[33]
Graphene oxide	GO	Intravitreal	Japanese white rabbit	Eyeball	[19]
Graphene oxide	¹²⁵I-NGS-PEG	Intravenous	BALB/c mice	Liver, spleen, and excreted in urine	[39]
Graphite nanoparticles	⁶⁰Co-Co/graphitic-shell nanocrystals	Intravenous	Kongming white mice	Liver, lungs, spleen	[25]
Graphite nanoparticles	Graphite nanoparticles	Intragastrically	Caenorhabditis elegans	Along the nematode body	[15]
Multi-walled carbon nanotubes	MWCNT	Intraperitoneal	Swiss-Webster mice	Liver	[35]
Multi-walled carbon nanotubes	¹²⁵I-tau-MWNTs	Intravenous	Kunming mice	Liver, lungs, spleen	[27]
Multi-walled carbon nanotubes	¹²⁵I-Tween-MWNTs	Intravenous	Kunming mice	Liver, lungs, spleen, stomach, kidney, large and small intestine	[27]
Nanodiamond	¹⁸⁸Re-NDs	Intratracheal	Kun Ming mice	Bones, heart, liver, lungs, spleen	[23]
Nanodiamond	NDs-4	Intratracheal	ICR mice	Lungs	[12]
Nanodiamond	NDs-50	Intratracheal	ICR mice	Lungs	[12]
Nanodiamond	¹²⁵I-NDs	Intravenous	ICR mice	Liver, lungs, spleen	[24]
Nanodiamond	¹⁸F-DNPs	Intravenous	Sprague-Dawley rats	Liver, lungs, spleen and excreted in urine	[13]
Nanodiamond	¹⁸F-DNPs	Intravenous	Swiss CD1 mice	Liver, lungs, spleen and excreted in urine	[13]
Nanodiamond	NDX (nanodiamond + DOX)	Intravenous	Sprague-Dawley rats BALB/c mice	Liver	[4]
Nanodiamond	DNX (nanodiamond + DOX)	Intravenous	Sprague-Dawley rats BALB/c mice	Lungs	[4]
Nanodiamond	RUDDM (Real-Dzerzhinsk ultra-disperse diamond modified)	Intravenous	Chinchilla rabbits	No aggregates but effects on biochemical blood parameters	[34]
Nanodiamond	RUDDM (Real-Dzerzhinsk ultra-disperse diamond modified)	Subcutaneous	ICR mice	Subcutaneous injection region, skin	[34]
Nanodiamond	Fluorescent nanodiamond	Gonad arms	Caenorhabditis elegans	Gonad, oocytes, early embryos	[26]
Nanodiamond	Fluorescent nanodiamond	Intragastrically	Caenorhabditis elegans	Gut (digestive track, after 20 min FND were excreted)—aggregates	[26]
Nanodiamond	Dextran-coated Fluorescent nanodiamond BSA-coated FND	Intragastrically	Caenorhabditis elegans	Intestinal cells	[26]
Single-walled carbon nanotubes	SWCNTs	Intravenous	CD-ICR mouse	Liver, lung, spleen	[28]
Single-walled carbon nanotubes	64Cu-labeled SWNT–PEG2000	Intravenous	Nude mice	Liver, kidney, spleen, intestine, lung	[36]
Single-walled carbon nanotubes	SWNT–PEG5400	Intravenous	Nude mice	Liver, kidney, spleen, intestine, lung	[36]

Back to article page

Search

Navigation