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Fig. 6 | Nanoscale Research Letters

Fig. 6

From: PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread

Fig. 6

Simultaneous incorporation of suberoylanilide hydroxamic acid (SAHA) and protease inhibitor nelfinavir (Nel) in scFv CD45RO-SAHA/Nel NPs can both activate latent HIV expression and inhibit viral spread. ACH-2 cells were incubated for 3 days in the presence of the indicated drug combinations delivered by NPs. Conditioned medium was transferred to naïve cells, and viral p24 protein in the culture supernatant was measured by ELISA. Error bars indicate the standard deviation of triplicate data points. Asterisk means significant difference as compared with the rest of the groups at P < 0.05

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