Skip to main content
Fig. 5 | Nanoscale Research Letters

Fig. 5

From: Encapsulation of Aconitine in Self-Assembled Licorice Protein Nanoparticles Reduces the Toxicity In Vivo

Fig. 5

Schematic diagram of formation and detoxification of GP-AC NPs. The hydrophilic surface of GP molecules, taking a polypeptide segment as example (bottom left in the diagram), is charged (shown as blue square and circular dot) in the aqueous solution while the hydrophobic groups (shapes in grey) are wrapping inside the molecule. When the solution pH was adjusted to near PI (pH = 5.0), the protein surface became partially uncharged (shown as hollow blue square and circle) which weakens the ionic dispelling force between protein molecules and facilitates the protein aggregation. The water insoluble AC binds to the hydrophobic regions of GP during the conformational changes thereafter is encapsulated in the protein NPs, namely GP-AC NPs. The protein encapsulation detoxified AC in the mouse

Back to article page